HCN4 and KCNE2

Number of citations of the paper that reports this interaction (PubMedID 12856183)
0

Data Source:
BioGRID (two hybrid)

		HCN4	KCNE2
Description		hyperpolarization activated cyclic nucleotide gated potassium channel 4	potassium voltage-gated channel subfamily E regulatory subunit 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Dendrite Monoatomic Ion Channel Complex Perinuclear Region Of Cytoplasm HCN Channel Complex	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Apical Plasma Membrane Monoatomic Ion Channel Complex
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Intracellularly CAMP-activated Cation Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding CAMP Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In SA Node Cell Action Potential Depolarization	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Regulation Of Heart Rate Sinoatrial Node Development Regulation Of Membrane Depolarization Monoatomic Ion Transport Monoatomic Cation Transport Potassium Ion Transport Sodium Ion Transport Muscle Contraction Blood Circulation Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cellular Response To CAMP Cellular Response To CGMP Potassium Ion Transmembrane Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Sodium Ion Import Across Plasma Membrane Regulation Of SA Node Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Potassium Ion Import Across Plasma Membrane	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Delayed Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane
Pathways		HCN channels	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs			Enflurane Promethazine Miconazole
Diseases		Brugada syndrome (BRS) Sick sinus syndrome (SSS); Sinus node dysfunction	Atrial fibrillation Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Atrial fibrillation ( 22544366 30061737 29892015 28416818) Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Heel bone mineral density ( 30598549) Nickel levels ( 26025379) PR interval ( 32439900) Resting heart rate ( 29769521 27798624) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index (smoking years interaction) ( 23192594) Cancer ( 29299148) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 28714974 33020668 32469254 26343387 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Heel bone mineral density ( 28869591 30598549) Height ( 31562340 20881960) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 28166213 30804560) Myocardial infarction ( 26343387 26708285) Myocardial infarction (early onset) ( 19198609) Pulmonary function ( 21946350)
Interacting Genes		2 interacting genes: HCN2 KCNE2	4 interacting genes: HCN2 HCN4 KCNH2 KCNQ1
Entrez ID		10021	9992
HPRD ID		09240	04813
Ensembl ID		ENSG00000138622	ENSG00000159197
Uniprot IDs		Q9Y3Q4	Q9Y6J6
PDB IDs		2MNG 3OTF 3U11 4HBN 4KL1 4NVP 6GYN 6GYO	2M0Q
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Activity Potassium Ion Import Across Plasma Membrane Potassium Channel Activity Inorganic Cation Import Across Plasma Membrane Voltage-gated Potassium Channel Complex Monoatomic Ion Channel Complex Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Response To Xenobiotic Stimulus HCN Channel Complex Cellular Response To CGMP Ammonium Transmembrane Transport Import Into Cell Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Cellular Response To Aldosterone Intracellularly CAMP-activated Cation Channel Activity Response To CGMP Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Cellular Response To Mineralocorticoid Stimulus Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Somatodendritic Compartment Membrane Depolarization During Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Inorganic Ion Transmembrane Transport Response To Aldosterone Ventricular Cardiac Muscle Cell Action Potential Potassium Ion Export Across Plasma Membrane CAMP Binding Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Inward Rectifier Potassium Channel Activity Sodium Ion Import Across Plasma Membrane Monoatomic Ion Transport Negative Regulation Of Transporter Activity Membrane Repolarization	Potassium Ion Import Across Plasma Membrane Voltage-gated Potassium Channel Activity Potassium Channel Activity Inorganic Cation Import Across Plasma Membrane Monoatomic Ion Channel Complex Import Across Plasma Membrane Potassium Ion Transmembrane Transport Membrane Depolarization During Action Potential Monoatomic Ion Channel Activity Potassium Ion Transport Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Cardiac Conduction Membrane Depolarization HCN Channel Complex Cellular Response To CAMP Voltage-gated Potassium Channel Complex Regulation Of Membrane Potential Response To CAMP Cellular Response To CGMP Regulation Of Heart Rate Action Potential Intracellularly CAMP-activated Cation Channel Activity Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Response To CGMP Response To Purine-containing Compound Inorganic Ion Transmembrane Transport Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Sodium Ion Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Contraction Muscle Contraction CAMP Binding Monoatomic Ion Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sodium Ion Import Across Plasma Membrane
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