RNH1 and RRM1

		RNH1	RRM1
Description		ribonuclease/angiogenin inhibitor 1	ribonucleotide reductase catalytic subunit M1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Lamellipodium Angiogenin-PRI Complex Extracellular Exosome	Nuclear Envelope Cytoplasm Mitochondrion Cytosol Ribonucleoside-diphosphate Reductase Complex Centriolar Satellite Ciliary Basal Body Cell Projection Neuronal Cell Body
	Molecular Function	Protein Binding Ribonuclease Inhibitor Activity	Nucleotide Binding Catalytic Activity Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Oxidoreductase Activity Purine Nucleotide Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding
	Biological Process	Cytoplasmic Translation MRNA Catabolic Process Cell Migration Negative Regulation Of Translation In Response To Stress Regulation Of Arp2/3 Complex-mediated Actin Nucleation TRNA Stabilization Regulation Of Angiogenesis	DNA Synthesis Involved In DNA Repair Pyrimidine Nucleobase Metabolic Process Mitochondrial DNA Replication DNA Repair Male Gonad Development Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye Positive Regulation Of G0 To G1 Transition Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Interconversion of nucleotide di- and triphosphates
Drugs			Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases
GWAS		Body mass index ( 25673413) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)	Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		5 interacting genes: ANG CEBPA OGT RNASE1 SDCBP	11 interacting genes: BMI1 CDC42 CEBPA LRIF1 PPP1CC RNF2 RRM2 RRM2B SUMO2 YWHAG ZNF655
Entrez ID		6050	6240
HPRD ID		01412	01588
Ensembl ID		ENSG00000023191	ENSG00000167325
Uniprot IDs		A0A140VJT8 P13489	B4DXD1 B4E0I8 E9PL69 P23921
PDB IDs		1A4Y 1Z7X 2BEX 2Q4G	2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L 6LKM
Enriched GO Terms of Interacting Partners?		Peptide Binding Hematopoietic Stem Cell Proliferation RNA Nuclease Activity Organelle Organization Negative Regulation Of RNA Metabolic Process Defense Response To Gram-positive Bacterium Endonuclease Activity Defense Response Regulation Of Phosphorus Metabolic Process Cell Communication Stem Cell Proliferation Response To Stress TRNA-specific Ribonuclease Activity Protein-containing Complex Organization Angiogenin-PRI Complex Nuclease Activity Macromolecule Biosynthetic Process Protein-containing Complex Assembly Animal Organ Development Cytoplasmic Translation Signaling Cellular Component Assembly Response To Hormone Cell Maturation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin DNA Binding CHOP-C/EBP Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Nutrient Response To Vitamin B2 White Fat Cell Proliferation Memory C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Telomere Tethering At Nuclear Periphery Nuclear Pore Cytoplasmic Filaments Ribonuclease A Activity Ribonucleoside-diphosphate Reductase Complex Positive Regulation Of G0 To G1 Transition Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Purine Nucleotide Binding Ribonucleoside-diphosphate Reductase Activity Interleukin-5 Receptor Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Regulation Of Extracellular Exosome Assembly	RING-like Zinc Finger Domain Binding Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Complex Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Regulation Of Store-operated Calcium Entry PRC1 Complex
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