REN and AGT

Number of citations: 40 (PubMedID 12045255)
Data Source: BioGRID (enzymatic study, x-ray crystallography, enzymatic study)

		REN	AGT
Name		renin	angiotensinogen
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Apical Part Of Cell	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Activity Aspartic-type Endopeptidase Activity Signaling Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding Peptidase Activity Hydrolase Activity	Serine-type Endopeptidase Inhibitor Activity Hormone Activity Protein Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Sodium Channel Regulator Activity Type 1 Angiotensin Receptor Binding Type 2 Angiotensin Receptor Binding Receptor Ligand Activity
	Biological Process	Kidney Development Mesonephros Development Angiotensin Maturation Regulation Of Blood Volume By Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Proteolysis Regulation Of Blood Pressure Male Gonad Development Response To Xenobiotic Stimulus Hormone-mediated Signaling Pathway Gene Expression Response To Lipopolysaccharide Response To Immobilization Stress Angiotensin-activated Signaling Pathway Drinking Behavior Regulation Of MAPK Cascade Cell Maturation Amyloid-beta Metabolic Process Response To CAMP Response To CGMP Cellular Response To Xenobiotic Stimulus Juxtaglomerular Apparatus Development	Regulation Of Cell Growth Positive Regulation Of Cytokine Production Kidney Development Blood Vessel Remodeling Regulation Of Blood Volume By Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Renal Output By Angiotensin Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Renal System Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Derived Foam Cell Differentiation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Regulation Of Vasoconstriction Positive Regulation Of Superoxide Anion Generation Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Nitric Oxide-cGMP-mediated Signaling Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Vasoconstriction Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Inflammatory Response Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Renal Sodium Ion Absorption Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Cholesterol Metabolic Process Blood Vessel Diameter Maintenance Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Extracellular Matrix Assembly Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Membrane Hyperpolarization Positive Regulation Of MiRNA Transcription Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Response To Angiotensin Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Metabolism of Angiotensinogen to Angiotensins	PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		Remikiren Minoxidil Lisinopril N,N-dimethylformamide Isoamyl alcohol 3-Phenyl-1,2-Propandiol 2-Methyl-3-(2-Aminothiazolo)Propanal Enalkiren 2-Cyclopropylmethylenepropanal 1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine N-Methyl-N-(Methylbenzyl)Formamide 1-Hydroxy-2-Amino-3-Cyclohexylpropane SPP1148 N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDE 6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINE N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE 6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE 6-ethyl-5-[(2S)-1-(3-methoxypropyl)-2-phenyl-1,2,3,4-tetrahydroquinolin-7-yl]pyrimidine-2,4-diamine Aliskiren	Zinc Copper Sparsentan Zinc acetate
Diseases		Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juvenile hyperuremic nephropathy; Glomerulocystic kidney disease Renal tubular dysgenesis	Renal tubular dysgenesis
GWAS		Blood protein levels in cardiovascular risk ( 28369058 ) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309 )	Blood protein levels ( 30072576 ) Coronary artery disease ( 33020668 29212778 ) Diastolic blood pressure ( 27618452 28739976 27841878 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Mean arterial pressure ( 27618448 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Pancreatic ductal adenocarcinoma ( 30541042 ) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309 ) Systolic blood pressure ( 27841878 27618452 30578418 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 )
Interacting Genes		9 interacting genes: AGT ATP6AP2 CCDC24 CTSB KCTD15 M6PR PCSK1 PCSK5 RENBP	24 interacting genes: ACE2 AGTR1 AGTR2 ATP6AP2 CMA1 CTSG DNPEP ECE1 ENPEP EWSR1 GRB2 GSDMB HSP90AA1 ITSN2 KNG1 LNPEP MAS1 MEP1A MME PRCP PREP PRG2 REN TP53
Entrez ID		5972	183
HPRD ID		01564	00106
Ensembl ID		ENSG00000143839	ENSG00000135744
Uniprot IDs		P00797	A0A7P0T8D1 B0ZBE2 B2R5S1 P01019
PDB IDs		1BBS 1BIL 1BIM 1HRN 1RNE 2BKS 2BKT 2FS4 2G1N 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26 2G27 2I4Q 2IKO 2IKU 2IL2 2REN 2V0Z 2V10 2V11 2V12 2V13 2V16 2X0B 3D91 3G6Z 3G70 3G72 3GW5 3K1W 3KM4 3O9L 3OAD 3OAG 3OOT 3OQF 3OQK 3OWN 3Q3T 3Q4B 3Q5H 3SFC 3VCM 3VSW 3VSX 3VUC 3VYD 3VYE 3VYF 4AMT 4GJ5 4GJ6 4GJ7 4GJ8 4GJ9 4GJA 4GJB 4GJC 4GJD 4PYV 4Q1N 4RYC 4RYG 4RZ1 4S1G 4XX3 4XX4 5KOQ 5KOS 5KOT 5SXN 5SY2 5SY3 5SZ9 5T4S 5TMG 5TMK 5V8V 5VPM 5VRP 6I3F 7XGK 7XGO 7XGP	1N9U 1N9V 2JP8 2WXW 2X0B 3CK0 3WOO 3WOR 4AA1 4APH 4FYS 5E2Q 5M3X 5M3Y 5XJM 6I3F 6I3I 6JOD 6OS0 7C6A
GO Terms Enriched among Interactors		Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Hormone Metabolic Process Regulation Of Hormone Levels Endopeptidase Activity Peptide Biosynthetic Process Protein Processing Proteolysis Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Peptide Metabolic Process Protein Maturation N-acylglucosamine 2-epimerase Activity Eye Pigmentation Regulation Of Biological Quality Positive Regulation Of Membrane Hyperpolarization G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Type 2 Angiotensin Receptor Binding N-acetylmannosamine Metabolic Process Central Nervous System Maturation Transport Vesicle Positive Regulation Of Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Regulation Of Renal Output By Angiotensin Peptidase Activity Rostrocaudal Neural Tube Patterning Lysosome Protein Secretion Establishment Of Protein Localization To Extracellular Region Protein Localization To Extracellular Region Serine-type Peptidase Activity Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Peptidase Inhibitor Complex Viral Life Cycle Renin Secretion Into Blood Stream Regulation Of Membrane Hyperpolarization Type 1 Angiotensin Receptor Binding Regulation Of Angiotensin-activated Signaling Pathway Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Endolysosome Lumen Secretion Of Lysosomal Enzymes Cytokine Precursor Processing Serine-type Endopeptidase Activity Cell-cell Signaling Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Gap Junction Assembly Anterior/posterior Pattern Specification N-acetylneuraminate Catabolic Process Positive Regulation Of Transforming Growth Factor Beta1 Production	Angiotensin Maturation Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Protein Processing Hormone Metabolic Process Protein Maturation Peptidase Activity Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Hormone Levels Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Biological Quality Regulation Of Systemic Arterial Blood Pressure Peptide Metabolic Process Metallopeptidase Activity Proteolysis Blood Vessel Diameter Maintenance Regulation Of Tube Size Peptide Catabolic Process Angiotensin Type II Receptor Activity Angiotensin-activated Signaling Pathway Neuropeptide Catabolic Process Hydrolase Activity Metallocarboxypeptidase Activity Vascular Process In Circulatory System Plasma Membrane Endopeptidase Activity Circulatory System Process Extracellular Exosome Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Oligopeptidase Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Substance P Catabolic Process Protein Metabolic Process Peptide Binding Aminopeptidase Activity System Process Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Circulation Regulation Of Blood Volume By Renin-angiotensin Negative Regulation Of Blood Pressure Bradykinin Catabolic Process Extracellular Region Vasodilation Positive Regulation Of Cardiac Muscle Contraction