CCM2

Description		CCM2 scaffold protein
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Protein-containing Complex
	Molecular Function	Protein Binding
	Biological Process	Blood Vessel Development Vasculogenesis In Utero Embryonic Development Endothelial Cell Development Vasculature Development Endothelium Development Integrin-mediated Signaling Pathway Heart Development Multicellular Organism Growth Cell-cell Junction Organization Regulation Of Angiogenesis Inner Ear Development Venous Blood Vessel Morphogenesis Stress-activated MAPK Cascade Pericardium Development Blood Vessel Endothelial Cell Differentiation Endothelial Tube Morphogenesis
Pathways
Drugs
Diseases		Cerebral cavernous malformation
GWAS		Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Myocardial infarction ( 33532862)
Interacting Genes		5 interacting genes: HOXC8 POT1 SMURF1 SRPK2 TLNRD1
Entrez ID		83605
HPRD ID		09719
Ensembl ID		ENSG00000136280
Uniprot IDs		B7Z8D5 Q9BSQ5
PDB IDs		4FQN 4TVQ 4WJ7 4Y5O 4YKC 4YKD 4YL6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Engulfment Of Target By Autophagosome Nuclear Speck Organization Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Single-stranded Telomeric DNA Binding Shelterin Complex Activin Receptor Binding R-loop Processing Telomerase Inhibitor Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly DEAD/H-box RNA Helicase Binding Establishment Of Protein Localization To Telomere Substrate Localization To Autophagosome G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly
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