RAPSN and CHRNB1

Number of citations of the paper that reports this interaction (PubMedID 16280586)
62

Data Source:
HPRD (in vivo)

		RAPSN	CHRNB1
Description		receptor associated protein of the synapse	cholinergic receptor nicotinic beta 1 subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Plasma Membrane Membrane Neuromuscular Junction Synapse Postsynaptic Membrane Postsynaptic Specialization Membrane	Plasma Membrane Acetylcholine-gated Channel Complex Membrane Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Postsynaptic Specialization Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Metal Ion Binding Structural Constituent Of Postsynaptic Specialization	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Channel Activity Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Junction Development Skeletal Muscle Acetylcholine-gated Channel Clustering Motor Neuron Apoptotic Process Maintenance Of Postsynaptic Specialization Structure Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Neuromuscular Synaptic Transmission Regulation Of Postsynaptic Membrane Organization Establishment Of Protein Localization To Postsynaptic Membrane Positive Regulation Of Motor Neuron Apoptotic Process	Postsynaptic Membrane Organization Skeletal Muscle Contraction Monoatomic Ion Transport Monoatomic Cation Transport Muscle Contraction Signal Transduction Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Monoatomic Ion Transmembrane Transport Behavioral Response To Nicotine Regulation Of Membrane Potential Nervous System Process Membrane Depolarization Muscle Cell Development Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway
Pathways
Drugs
Diseases		Congenital myasthenic syndrome Fetal akinesia deformation sequence (FADS); Pena-Shokeir syndrome, type 1	Congenital myasthenic syndrome
GWAS		Alcohol consumption (drinks per week) ( 30679032 30643258) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159) Diastolic blood pressure ( 27618452 28739976) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 33627673) Global electrical heterogeneity phenotypes ( 29622589) Height ( 28552196) Intraocular pressure ( 29235454 29617998 25173106) Lacunar stroke ( 33773637) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mood instability ( 31168069) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 27618452 28739976) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 29403010)	Brain morphology (MOSTest) ( 32665545) Emotional recognition ( 31596458) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: CHRNA4 CHRNB1 DAG1 GRB2 KHDRBS1 KLHL8 MUSK TRIM54 UBE2Z	3 interacting genes: ASB6 COPS6 RAPSN
Entrez ID		5913	1140
HPRD ID		03353	01156
Ensembl ID		ENSG00000165917	ENSG00000170175
Uniprot IDs		A0A0S2Z4A2 A0A0S2Z4A6 A0A0S2Z4F8 A0A0S2Z4M9 Q13702	P11230
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Binding Behavioral Response To Nicotine Postsynaptic Membrane Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine-gated Channel Complex Schwann Cell Development Synaptic Transmission, Cholinergic Ligand-gated Monoatomic Ion Channel Activity Neuromuscular Synaptic Transmission Extracellular Ligand-gated Monoatomic Ion Channel Activity SH2 Domain Binding Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Membrane Depolarization Excitatory Postsynaptic Potential Muscle Attachment Glial Cell Development Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Protein Geranylgeranylation Grb2-Sos Complex Trans-synaptic Signaling Synaptic Signaling Neuromuscular Junction Synapse Calcium-dependent Cell-matrix Adhesion Myelination Axon Ensheathment Grb2-EGFR Complex Regulation Of Postsynaptic Membrane Potential SH3 Domain Binding Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Nerve Maturation Cell-cell Signaling Monoatomic Ion Channel Activity Signaling Adult Behavior Response To Denervation Involved In Regulation Of Muscle Adaptation Morphogenesis Of A Branching Structure Trans-synaptic Signaling By Trans-synaptic Complex Morphogenesis Of A Branching Epithelium Laminin-1 Binding Schwann Cell Differentiation Photoreceptor Ribbon Synapse Dystroglycan Complex Contractile Ring Antigen Receptor-mediated Signaling Pathway Neurotrophin TRKA Receptor Binding Positive Regulation Of RNA Export From Nucleus Cell Communication	Structural Constituent Of Postsynaptic Specialization Positive Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Neuromuscular Synaptic Transmission Regulation Of Postsynaptic Membrane Organization Regulation Of Motor Neuron Apoptotic Process Skeletal Muscle Acetylcholine-gated Channel Clustering Maintenance Of Postsynaptic Specialization Structure Establishment Of Protein Localization To Postsynaptic Membrane Motor Neuron Apoptotic Process Acetylcholine Receptor Binding Protein Deneddylation Metal-dependent Deubiquitinase Activity Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Density Organization Regulation Of Protein Neddylation Protein Neddylation Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Postsynaptic Specialization Organization Maintenance Of Synapse Structure Synaptic Transmission, Cholinergic Ionotropic Glutamate Receptor Binding Postsynaptic Specialization Membrane Protein-membrane Adaptor Activity COP9 Signalosome Protein Modification By Small Protein Conjugation Neuromuscular Junction Development Post-translational Protein Modification Receptor Clustering Receptor Localization To Synapse Cell Junction Maintenance Protein Localization To Synapse Cellular Component Maintenance Positive Regulation Of Neuron Apoptotic Process Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Protein Localization To Cell Junction
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