CHRNB1

Description		cholinergic receptor nicotinic beta 1 subunit
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Membrane Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Postsynaptic Specialization Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Channel Activity Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Postsynaptic Membrane Organization Skeletal Muscle Contraction Monoatomic Ion Transport Monoatomic Cation Transport Muscle Contraction Signal Transduction Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Monoatomic Ion Transmembrane Transport Behavioral Response To Nicotine Regulation Of Membrane Potential Nervous System Process Membrane Depolarization Muscle Cell Development Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway
Pathways
Drugs
Diseases		Congenital myasthenic syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Emotional recognition ( 31596458) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: ASB6 COPS6 RAPSN
Entrez ID		1140
HPRD ID		01156
Ensembl ID		ENSG00000170175
Uniprot IDs		P11230
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Postsynaptic Specialization Positive Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Neuromuscular Synaptic Transmission Regulation Of Postsynaptic Membrane Organization Regulation Of Motor Neuron Apoptotic Process Skeletal Muscle Acetylcholine-gated Channel Clustering Maintenance Of Postsynaptic Specialization Structure Establishment Of Protein Localization To Postsynaptic Membrane Motor Neuron Apoptotic Process Acetylcholine Receptor Binding Protein Deneddylation Metal-dependent Deubiquitinase Activity Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Density Organization Regulation Of Protein Neddylation Protein Neddylation Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Postsynaptic Specialization Organization Maintenance Of Synapse Structure Synaptic Transmission, Cholinergic Ionotropic Glutamate Receptor Binding Postsynaptic Specialization Membrane Protein-membrane Adaptor Activity COP9 Signalosome Protein Modification By Small Protein Conjugation Neuromuscular Junction Development Post-translational Protein Modification Receptor Clustering Receptor Localization To Synapse Cell Junction Maintenance Protein Localization To Synapse Cellular Component Maintenance Positive Regulation Of Neuron Apoptotic Process Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Protein Localization To Cell Junction
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