RAP1GDS1 and ABCB7

		RAP1GDS1	ABCB7
Description		Rap1 GTPase-GDP dissociation stimulator 1	ATP binding cassette subfamily B member 7
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GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity	Nucleotide Binding Protein Binding ATP Binding Heme Transmembrane Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity ABC-type Transporter Activity ABC-type Iron-sulfur Cluster Transporter Activity
	Biological Process	Cardiac Muscle Hypertrophy Regulation Of Mitochondrion Organization Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Protein Localization To Nucleus Positive Regulation Of Mitochondrial Calcium Ion Concentration Regulation Of ERK5 Cascade CAAX-box Protein Maturation Angiotensin-activated Signaling Pathway Involved In Heart Process Regulation Of Matrix Metallopeptidase Secretion	Intracellular Iron Ion Homeostasis Heme Transport Iron-sulfur Cluster Assembly Iron Ion Transmembrane Transport Transmembrane Transport Positive Regulation Of Heme Biosynthetic Process Iron-sulfur Cluster Export From The Mitochondrion Positive Regulation Of Iron-sulfur Cluster Assembly Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		RHOT2 GTPase cycle RHOT1 GTPase cycle	Mitochondrial ABC transporters Cytosolic iron-sulfur cluster assembly
Drugs
Diseases			Sideroblastic anemia, including: Pyridoxine-refractory autosomal recessive sideroblastic anemia (PRARSA); X-linked sideroblastic anemia (XLSA); X-linked sideroblastic anemia with ataxia (ASAT)
GWAS		Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)	Metabolite levels ( 23823483)
Interacting Genes		23 interacting genes: AKT1 CDC42 DIRAS1 DOC2A EGFR HRAS KIFAP3 KRAS LCOR MBIP NRAS OGT PLEKHB1 PTPRF PUF60 RAC1 RAP1A RAP2B RHOA RNF19B RRAS2 UBC ZNF451	3 interacting genes: APP FECH UBC
Entrez ID		5910	22
HPRD ID		11763	02137
Ensembl ID		ENSG00000138698	ENSG00000131269
Uniprot IDs		B3KNU0 P52306 Q6U7G8	A0A087WW65 A0A0S2Z2Z3 O75027
PDB IDs		5XGC 5ZHX	7VGF
Enriched GO Terms of Interacting Partners?		G Protein Activity GTPase Activity GDP Binding GTP Binding Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Glutamatergic Synapse Regulation Of Protein Localization To Membrane Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Migration Regulation Of Protein Phosphorylation Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Cell Motility Endoplasmic Reticulum Membrane Regulation Of Locomotion Positive Regulation Of Locomotion Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Phosphorylation Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Modification Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ras Protein Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Positive Regulation Of Epithelial Cell Proliferation Cerebral Cortex Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Modification Process Regulation Of Developmental Process Postsynapse Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Forebrain Radial Glial Cell Differentiation Cell Development Telencephalon Cell Migration Focal Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Apoptotic Process Positive Regulation Of Cell Cycle Process Cell Migration Forebrain Cell Migration	Response To Lead Ion Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Monoatomic Cation Homeostasis Mitochondrion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Detection Of UV Ferrochelatase Activity CAAX-box Protein Maturation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Chemical Homeostasis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Tetrapyrrole Binding Iron-responsive Element Binding Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Response To Platinum Ion Myosin Filament Assembly Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Response To Methylmercury Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Axon Choice Point Recognition Homeostatic Process
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