ABCB7 and FECH

Number of citations of the paper that reports this interaction (PMID 12480705)
12

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo)

		ABCB7	FECH
Gene Name		ATP-binding cassette, sub-family B (MDR/TAP), member 7	ferrochelatase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane	Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	ATP Binding Heme Transporter Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances	Ferrochelatase Activity Protein Binding Ferrous Iron Binding Heme Binding Iron-responsive Element Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Transport Cellular Iron Ion Homeostasis Heme Transport Small Molecule Metabolic Process Transmembrane Transport	Generation Of Precursor Metabolites And Energy Porphyrin-containing Compound Metabolic Process Heme Biosynthetic Process Cholesterol Metabolic Process Response To Light Stimulus Detection Of UV Response To Lead Ion Regulation Of Gene Expression Regulation Of EIF2 Alpha Phosphorylation By Heme Response To Insecticide Erythrocyte Differentiation Very-low-density Lipoprotein Particle Assembly Response To Drug Small Molecule Metabolic Process Response To Ethanol Protoporphyrinogen IX Metabolic Process Response To Arsenic-containing Substance Regulation Of Hemoglobin Biosynthetic Process Response To Methylmercury Iron Ion Homeostasis Response To Platinum Ion Cellular Response To Dexamethasone Stimulus
Pathways		Mitochondrial ABC transporters ABC-family proteins mediated transport Cytosolic iron-sulfur cluster assembly	Heme biosynthesis Metabolism of porphyrins
Drugs			Cholic Acid
Diseases
GWAS
Protein-Protein Interactions		2 interactors: APP FECH	1 interactors: ABCB7
Entrez ID		22	2235
HPRD ID		02137	01509
Ensembl ID		ENSG00000131269
Uniprot IDs		B4DGL8 G3XAC4 O75027 Q7Z3K5	B4DSA4 P22830 Q7KZA3
PDB IDs			1HRK 2HRC 2HRE 2PNJ 2PO5 2PO7 2QD1 2QD2 2QD3 2QD4 2QD5 3AQI 3HCN 3HCO 3HCP 3HCR 4F4D 4MK4
Enriched GO Terms of Interacting Partners?		Cholesterol Metabolic Process Sterol Metabolic Process Transition Metal Ion Homeostasis Detection Of UV Steroid Metabolic Process Regulation Of EIF2 Alpha Phosphorylation By Heme Response To Platinum Ion Synaptic Growth At Neuromuscular Junction Response To Light Stimulus Alcohol Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Hemoglobin Biosynthetic Process Response To Radiation Collateral Sprouting Axon Midline Choice Point Recognition Metal Ion Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Ion Homeostasis Very-low-density Lipoprotein Particle Assembly Neuron Remodeling Response To Methylmercury Protoporphyrinogen IX Metabolic Process Chemical Homeostasis Protein-lipid Complex Assembly Response To Insecticide Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Heme Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Response To Arsenic-containing Substance Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Response To Lead Ion Cellular Response To Dexamethasone Stimulus Porphyrin-containing Compound Biosynthetic Process Mating Behavior Response To Dexamethasone Endoplasmic Reticulum Calcium Ion Homeostasis Lipid Metabolic Process RNA Polyadenylation Neuron Recognition Regulation Of Phosphorylation Heme Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Homeostatic Process	Heme Transport Cofactor Transport Cellular Iron Ion Homeostasis Iron Ion Homeostasis Transition Metal Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis
Tagcloud ?		advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome	abcb6 ambp antioxidant beyond candidates chosen erythroid erythropoiesis followup fth1 ftl globin heme heterodimerizes hrg isothiocyanate k562 keap1 lymphoid maf nfe2 nfe2l2 nqo1 nrf2 seq sfn slc48a1 sulforaphane tbxas1
Tagcloud (Difference) ?		advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi exon hnrnpd leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome	abcb6 ambp antioxidant beyond candidates chosen erythropoiesis followup fth1 ftl globin heme heterodimerizes hrg isothiocyanate k562 keap1 lymphoid maf nfe2 nfe2l2 nqo1 nrf2 seq sfn slc48a1 sulforaphane tbxas1
Tagcloud (Intersection) ?		erythroid