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RFC3 and CHTF18
Number of citations of the paper that reports this interaction (PMID
12930902
)
41
Data Source:
BioGRID
(pull down, affinity chromatography technology)
RFC3
CHTF18
Gene Name
replication factor C (activator 1) 3, 38kDa
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
DNA Replication Factor C Complex
Nucleoplasm
Cytoplasm
Membrane
Molecular Function
DNA Binding
DNA Clamp Loader Activity
Protein Binding
ATPase Activity
DNA Binding
ATP Binding
Biological Process
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Strand Elongation Involved In DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
Response To Organophosphorus
DNA Replication
Reciprocal Meiotic Recombination
Male Meiosis
Spermatogenesis
Negative Regulation Of Chromosome Segregation
Pathways
Polymerase switching on the C-strand of the telomere
Nucleotide Excision Repair
Synthesis of DNA
Chromosome Maintenance
Lagging Strand Synthesis
Gap-filling DNA repair synthesis and ligation in TC-NER
G2/M Checkpoints
Extension of Telomeres
Repair synthesis for gap-filling by DNA polymerase in TC-NER
S Phase
Telomere C-strand (Lagging Strand) Synthesis
Leading Strand Synthesis
DNA strand elongation
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Cell Cycle, Mitotic
Gap-filling DNA repair synthesis and ligation in GG-NER
Polymerase switching
Global Genomic NER (GG-NER)
Telomere Maintenance
Transcription-coupled NER (TC-NER)
Activation of ATR in response to replication stress
Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Alzheimer's disease (
20061627
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
9 interactors:
ARFGAP1
BRD4
CHTF18
CHTF8
MESDC2
PCNA
RAD17
RFC1
RFC4
4 interactors:
PCNA
RFC3
RFC4
RFC5
Entrez ID
5983
63922
HPRD ID
02676
13059
Ensembl ID
ENSG00000133119
ENSG00000127586
Uniprot IDs
P40938
Q8WVB6
PDB IDs
Enriched GO Terms of Interacting Partners
?
DNA Replication
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
Cell Cycle
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
Transcription-coupled Nucleotide-excision Repair
Cell Cycle Process
DNA Metabolic Process
DNA Recombination
Telomere Maintenance
Mitotic Cell Cycle
Cellular Response To Stress
Nucleotide-excision Repair
Cellular Response To DNA Damage Stimulus
DNA-dependent DNA Replication
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Repair
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Nuclease Activity
Nucleobase-containing Compound Metabolic Process
Organelle Organization
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Chromosome Organization
Positive Regulation Of Deoxyribonuclease Activity
Cellular Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Response To Stress
Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain
Leading Strand Elongation
Nitrogen Compound Metabolic Process
Regulation Of DNA Replication
Negative Regulation Of DNA Damage Checkpoint
Histone H3-K14 Acetylation
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Process
Cellular Homeostasis
Methotrexate Transport
Cellular Response To Stimulus
Histone H4-K12 Acetylation
Folic Acid Transport
Telomere Maintenance Via Telomerase
Mitotic Cell Cycle Phase Transition
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
Transcription-coupled Nucleotide-excision Repair
Telomere Maintenance
Nucleotide-excision Repair
DNA-dependent DNA Replication
DNA Recombination
DNA Replication
DNA Repair
Cellular Homeostasis
Mitotic Cell Cycle
Cellular Response To DNA Damage Stimulus
Chromosome Organization
Cell Cycle Process
DNA Metabolic Process
Cell Cycle
Homeostatic Process
Cellular Response To Stress
DNA Biosynthetic Process
Positive Regulation Of Deoxyribonuclease Activity
Leading Strand Elongation
Organelle Organization
Response To Stress
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Translesion Synthesis
Cellular Nitrogen Compound Metabolic Process
DNA Synthesis Involved In DNA Repair
Nitrogen Compound Metabolic Process
Postreplication Repair
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Cellular Response To Stimulus
Positive Regulation Of Nuclease Activity
Response To Cadmium Ion
Mismatch Repair
Base-excision Repair
Response To Stimulus
Regulation Of DNA Replication
Positive Regulation Of DNA Metabolic Process
Response To Organophosphorus
Tagcloud
?
12q24
13q12
3q27
7q11
bands
catalyzed
chains
chromosomes
consisting
dnas
elongation
epsilon
hybrids
locations
mapped
multimeric
p145
p36
p37
p38
p40
panel
primer
processive
q13
q24
rfc2
rfc4
rfc5
Tagcloud (Difference)
?
12q24
13q12
3q27
7q11
bands
catalyzed
chains
chromosomes
consisting
dnas
elongation
epsilon
hybrids
locations
mapped
multimeric
p145
p36
p37
p38
p40
panel
primer
processive
q13
q24
rfc2
rfc4
rfc5
Tagcloud (Intersection)
?