RAC3 and ARHGDIA

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		RAC3	ARHGDIA
Gene Name		ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	Rho GDP dissociation inhibitor (GDI) alpha
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Endomembrane System Lamellipodium Growth Cone Filamentous Actin Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery	Immunological Synapse Cytosol Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding Calcium-dependent Protein Binding	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Metabolic Process Cell Projection Assembly Actin Cytoskeleton Organization Neuron Projection Development Positive Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Movement Of Cell Or Subcellular Component Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Negative Regulation Of Cell Migration Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway
Pathways		Rho GTPase cycle Signaling by Rho GTPases Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling	Rho GTPase cycle Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis Axonal growth stimulation Signaling by Rho GTPases p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ANKRD11 AR ARHGDIA ARHGDIB CIB1 ESR1 HNF1A NRBP1 RARA	36 interactors: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B FEN1 HAAO HERPUD1 IKBKG JUP MAPK6 NEDD4L POT1 RAC1 RAC2 RAC3 RDX RHOA RHOG RHOH SDHC SH3GL3 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2L6 UBE2R2 UFM1 VAV1
Entrez ID		5881	396
HPRD ID		03629	03565
Ensembl ID		ENSG00000169750	ENSG00000141522
Uniprot IDs		P60763	J3QQX2 J3QW41 P52565
PDB IDs		2C2H 2G0N 2IC5 2OV2 2QME	1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway Developmental Process Involved In Reproduction Steroid Hormone Mediated Signaling Pathway Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Hormone-mediated Signaling Pathway Regulation Of Signaling Multicellular Organismal Development Intracellular Estrogen Receptor Signaling Pathway Growth Gland Development Reproductive Structure Development Reproductive System Development Cellular Response To Steroid Hormone Stimulus Single Organism Reproductive Process Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Cell Adhesion Reproductive Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Developmental Process Regulation Of Apoptotic Process Response To Organic Substance Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Cell Death System Development Regulation Of Protein Localization Sex Differentiation Positive Regulation Of Cell Proliferation Face Development Regulation Of Protein Localization To Plasma Membrane Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Organ Development Negative Regulation Of Programmed Cell Death Cellular Response To Organic Substance Negative Regulation Of Cell Death Urogenital System Development Organ Morphogenesis Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Male Germ Cell Proliferation	Response To Stress Response To Stimulus Cellular Response To Stimulus Homeostatic Process Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Lengthening Intracellular Signal Transduction Positive Regulation Of Cell Death Signaling Negative Regulation Of Telomere Maintenance Positive Regulation Of Cellular Component Biogenesis Cell Communication Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Cell Projection Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Catalytic Activity Regulation Of DNA Replication Positive Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Positive Regulation Of Lamellipodium Organization Positive Regulation Of Programmed Cell Death Small GTPase Mediated Signal Transduction Blood Coagulation Regulation Of Telomere Maintenance Hemostasis Response To Abiotic Stimulus Regulation Of Signaling Telomere Maintenance Regulation Of Catalytic Activity Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Lamellipodium Assembly Response To Wounding Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Organic Substance
Tagcloud ?		accessible acetyltransferases aspects cloned coactivator concert condensed cor corepressor corepressors deacetylases entry era establish extensively generate hormone initiate modulate replaced repressed repression smrt src1 steroid theme tif2 transcriptionally unliganded	3p 5p biogenesis bioinformatics biologically compete complementary conversely counterparts e2f6 experimentally hence intermediates mature mere micrornas mir mirna mirnas pipeline precursors pri regulators repression separate serve snai2 untranslated utr
Tagcloud (Difference) ?		accessible acetyltransferases aspects cloned coactivator concert condensed cor corepressor corepressors deacetylases entry era establish extensively generate hormone initiate modulate replaced repressed smrt src1 steroid theme tif2 transcriptionally unliganded	3p 5p biogenesis bioinformatics biologically compete complementary conversely counterparts e2f6 experimentally hence intermediates mature mere micrornas mir mirna mirnas pipeline precursors pri regulators separate serve snai2 untranslated utr
Tagcloud (Intersection) ?		repression