GNGT1 and NAGA

Number of citations of the paper that reports this interaction (PubMedID 10360181)
0

Data Source:
HPRD (in vitro)

		GNGT1	NAGA
Description		G protein subunit gamma transducin 1	alpha-N-acetylgalactosaminidase
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Heterotrimeric G-protein Complex Plasma Membrane Membrane Photoreceptor Disc Membrane	Cytoplasm Lysosome Membrane Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding G-protein Beta-subunit Binding	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-galactosidase Activity Alpha-N-acetylgalactosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Homodimerization Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phototransduction Intracellular Protein Localization Cardiac Muscle Cell Apoptotic Process Eye Photoreceptor Cell Development Cellular Response To Hypoxia	Carbohydrate Metabolic Process Lipid Metabolic Process Oligosaccharide Metabolic Process Carbohydrate Catabolic Process Glycoside Catabolic Process Glycolipid Catabolic Process
Pathways		Activation of G protein gated Potassium channels G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Glycerin
Diseases			Alpha-N-acetylgalactosaminidase deficiency, including: Schindler disease; Kanzaki disease
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 28552196) Body size at age 10 ( 32376654) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mosquito bite size ( 28199695) Resting heart rate ( 27798624 29769521) Taxane-induced peripheral neuropathy in breast cancer ( 29278617)	Autism spectrum disorder or schizophrenia ( 28540026) Breast size ( 22747683) Intelligence ( 28530673) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		14 interacting genes: GNAS GNB1 GNB2 GNB4 GNB5 GORASP2 IKBKG MSANTD4 NAGA PDCL PLEKHB1 RHO UBXN4 ZNF277	2 interacting genes: APP GNGT1
Entrez ID		2792	4668
HPRD ID		01805	00076
Ensembl ID		ENSG00000127928	ENSG00000198951
Uniprot IDs		P63211	P17050
PDB IDs		7L0P 7L0Q 7L0R 7L0S	3H53 3H54 3H55 3IGU 4DO4 4DO5 4DO6
Enriched GO Terms of Interacting Partners?		Heterotrimeric G-protein Complex Signaling Receptor Complex Adaptor Activity G Protein-coupled Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway GTPase Activity Response To Catecholamine Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus Response To Light Intensity Photoreceptor Disc Membrane Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Sensory Perception GTPase Binding Phototransduction Alpha-N-acetylgalactosaminidase Activity Heterotrimeric G-protein Complex Assembly Rod Bipolar Cell Differentiation GTPase Activator Complex G-protein Gamma-subunit Binding Detection Of Light Stimulus Mu-type Opioid Receptor Binding Photoreceptor Outer Segment Alpha-galactosidase Activity Thermotaxis Dark Adaptation Retina Development In Camera-type Eye Signal Transduction Response To Light Stimulus Sperm Head Plasma Membrane Linear Polyubiquitin Binding Light Adaption Response To Unfolded Protein Protein-containing Complex Binding Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Lysosomal Membrane Photoreceptor Inner Segment Membrane Absorption Of Visible Light Sensory Perception Of Chemical Stimulus Cellular Response To Light Stimulus Hair Follicle Placode Formation Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Thermoception G Protein-coupled Opsin Signaling Pathway 11-cis Retinal Binding Detection Of Abiotic Stimulus Nervous System Process	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Light Stimulus Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Response To Radiation Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Apoptotic Process Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle
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