GNGT1 and ZNF277

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		GNGT1	ZNF277
Description		G protein subunit gamma transducin 1	zinc finger protein 277
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Heterotrimeric G-protein Complex Plasma Membrane Membrane Photoreceptor Disc Membrane	Nucleus
	Molecular Function	GTPase Activity Protein Binding G-protein Beta-subunit Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phototransduction Intracellular Protein Localization Cardiac Muscle Cell Apoptotic Process Eye Photoreceptor Cell Development Cellular Response To Hypoxia	Cellular Response To Hydrogen Peroxide Regulation Of Cellular Senescence
Pathways		Activation of G protein gated Potassium channels G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 28552196) Body size at age 10 ( 32376654) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mosquito bite size ( 28199695) Resting heart rate ( 27798624 29769521) Taxane-induced peripheral neuropathy in breast cancer ( 29278617)	Breast size ( 22747683) Early-onset Parkinson's disease ( 28256260) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: GNAS GNB1 GNB2 GNB4 GNB5 GORASP2 IKBKG MSANTD4 NAGA PDCL PLEKHB1 RHO UBXN4 ZNF277	10 interacting genes: CDCA8 COIL DDB1 GNGT1 MBD3 NUTM1 OGT RPP14 ZBTB7B ZNF768
Entrez ID		2792	11179
HPRD ID		01805	05680
Ensembl ID		ENSG00000127928	ENSG00000198839
Uniprot IDs		P63211	Q9NRM2
PDB IDs		7L0P 7L0Q 7L0R 7L0S
Enriched GO Terms of Interacting Partners?		Heterotrimeric G-protein Complex Signaling Receptor Complex Adaptor Activity G Protein-coupled Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway GTPase Activity Response To Catecholamine Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus Response To Light Intensity Photoreceptor Disc Membrane Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Sensory Perception GTPase Binding Phototransduction Alpha-N-acetylgalactosaminidase Activity Heterotrimeric G-protein Complex Assembly Rod Bipolar Cell Differentiation GTPase Activator Complex G-protein Gamma-subunit Binding Detection Of Light Stimulus Mu-type Opioid Receptor Binding Photoreceptor Outer Segment Alpha-galactosidase Activity Thermotaxis Dark Adaptation Retina Development In Camera-type Eye Signal Transduction Response To Light Stimulus Sperm Head Plasma Membrane Linear Polyubiquitin Binding Light Adaption Response To Unfolded Protein Protein-containing Complex Binding Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Lysosomal Membrane Photoreceptor Inner Segment Membrane Absorption Of Visible Light Sensory Perception Of Chemical Stimulus Cellular Response To Light Stimulus Hair Follicle Placode Formation Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Thermoception G Protein-coupled Opsin Signaling Pathway 11-cis Retinal Binding Detection Of Abiotic Stimulus Nervous System Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?