PTPRZ1 and AASS

		PTPRZ1	AASS
Description		protein tyrosine phosphatase receptor type Z1	aminoadipate-semialdehyde synthase
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Extracellular Matrix Synapse Perineuronal Net	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Hydrolase Activity	Transcription Corepressor Activity Catalytic Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Oxidoreductase Activity Histone Binding Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Protein Dephosphorylation Signal Transduction Axonogenesis Central Nervous System Development Learning Or Memory Neuron Projection Development Regulation Of Myelination Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Lysine Catabolic Process L-lysine Catabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine
Pathways		Other interleukin signaling MDK and PTN in ALK signaling	Lysine catabolism
Drugs			Glutamic acid NADH NADPH L-Saccharopine
Diseases			Hyperlysinemia
GWAS		Hand grip strength ( 27325353) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730)	Opioid dependence (time to event) ( 34124712)
Interacting Genes		13 interacting genes: ADD2 ALK ARHGAP35 CTNNB1 FYN GIT1 HMGB1 IL34 MDK MGAT5B PTN PTPRF TNR	2 interacting genes: OGT WEE2-AS1
Entrez ID		5803	10157
HPRD ID		01481	05489
Ensembl ID		ENSG00000106278	ENSG00000008311
Uniprot IDs		B4DFE7 P23471	A0A7P0T9N4 A4D0W4 Q9UDR5
PDB IDs		3JXF 3S97 5AWX 5H08 8FN8 8FN9	5L76 5L78 5O1N 5O1O 5O1P 8DDA 8E8T 8E8U 8E8V
Enriched GO Terms of Interacting Partners?		Regulation Of Response To Wounding Cell Migration Regulation Of Oligodendrocyte Differentiation Regulation Of Neuron Projection Development Cell Motility Positive Regulation Of Neuron Projection Development Regulation Of Glial Cell Differentiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Developmental Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Component Organization Regulation Of Cell Projection Organization Leukocyte Migration Regulation Of Gliogenesis Schaffer Collateral - CA1 Synapse Positive Regulation Of Leukocyte Chemotaxis Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Development Learning Or Memory Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Glial Cell Differentiation Cell Development Nervous System Development Cognition Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Growth Factor Activity Heparin Binding Positive Regulation Of Blood Vessel Branching Learning Positive Regulation Of Cell Projection Organization Regulation Of Multicellular Organismal Development Regulation Of Neurogenesis Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway System Development Regulation Of Blood Vessel Branching Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Gliogenesis Positive Regulation Of Epithelial Cell Proliferation Response To Mechanical Stimulus Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Development
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