NCOA5 and NR1D2

Number of citations of the paper that reports this interaction (PubMedID 11113208)
66

Data Source:
HPRD (two hybrid, in vitro)

		NCOA5	NR1D2
Description		nuclear receptor coactivator 5	nuclear receptor subfamily 1 group D member 2
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Actin Cytoskeleton	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Insulin Receptor Signaling Pathway Regulation Of Signal Transduction Glucose Homeostasis Negative Regulation Of Insulin Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Hormone-mediated Signaling Pathway Regulation Of Lipid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Circadian Behavior Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Lipid Homeostasis Energy Homeostasis Regulation Of Skeletal Muscle Cell Differentiation
Pathways			Nuclear Receptor transcription pathway
Drugs		17alpha-Estriol	SR-9009 SR-9011
Diseases
GWAS		Crohn's disease ( 28067908) Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831) Follicular lymphoma or multiple sclerosis ( 31407831) HDL cholesterol levels ( 32203549) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 28067908) Marginal zone lymphoma or multiple sclerosis ( 31407831) Multiple sclerosis ( 21833088 31604244) Systemic lupus erythematosus ( 28714469) Tonsillectomy ( 27182965 28928442)	Acne (severe) ( 24927181) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Asthma ( 29273806) Cognitive ability ( 29186694) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483) Parkinson's disease progression (cognitive) ( 33111402) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: ACOT7 ATOSB CCDC57 CDC37 GORASP2 HTATIP2 KANK2 KHDRBS2 KHDRBS3 MEIG1 NR1D2 NTAQ1 PICK1 RAB30 SYT16 TSC22D1 TSGA10IP UBL5 ZNF326	54 interacting genes: CRY1 CSNK1E CSNK2A2 CUL1 CYSRT1 DELEC1 EFEMP2 GTF2B HDAC1 HOXA1 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-6 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-8 LGALS8 MEOX2 MID2 MYLIP MYO15B NBPF19 NCOA5 NCOR1 NOTCH2NLA NR1D1 PCSK5 PRMT6 PROP1 RBPMS RGN RORC SIN3B TAF6 TAF9 TBC1D21 TENT5B TRIM27 TRIM55 TRIM63 TRIP6 TTC3 UBE2I ZNF587
Entrez ID		57727	9975
HPRD ID		14813	03809
Ensembl ID		ENSG00000124160	ENSG00000174738
Uniprot IDs		Q9HCD5	B4DXD3 F1D8P2 Q14995
PDB IDs		1V95 2J7X 2J7Y 4ZI1	2V0V 2V7C 3CQV 4N73 6WMQ 6WMS
Enriched GO Terms of Interacting Partners?			Intermediate Filament Keratin Filament Circadian Regulation Of Gene Expression Circadian Rhythm Negative Regulation Of Catabolic Process Nuclear Thyroid Hormone Receptor Binding Rhythmic Process Transcription Factor TFIID Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Circadian Rhythm RNA Polymerase II Preinitiation Complex Assembly Cytosol
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