IGSF9 and CYB5B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IGSF9	CYB5B
Description		immunoglobulin superfamily member 9	cytochrome b5 type B
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Dendrite Synapse Inhibitory Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle Nitric-oxide Synthase Complex
	Molecular Function	Protein Binding Cell-cell Adhesion Mediator Activity	Protein Binding Heme Binding Metal Ion Binding Nitrite Reductase (NO-forming) Activity
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Dendrite Development Cell Differentiation Regulation Of Synapse Organization Dendrite Self-avoidance Regulation Of Synapse Maturation	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress
Pathways			Sphingolipid de novo biosynthesis eNOS activation Phase I - Functionalization of compounds
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Blood osmolality (transformed sodium) ( 28360221) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Serum uric acid levels ( 29403010 30993211)
Interacting Genes		5 interacting genes: ASCC2 CYB5B PAQR5 SHANK3 TMEM65	51 interacting genes: AHNAK2 APP AQP6 BIK BNIP3L BTNL9 CD33 CD79A CGRRF1 CLDN7 CLN8 CPLX4 CREB3 EBP ERGIC3 FAM209A FAM210B FKBP7 FNDC9 FRMD3 GJB5 GPR152 IGSF9 KCNK5 KIR2DL3 LMNA MARCHF8 MFF MUC1 NDUFAF2 PDZK1IP1 PHACTR3 PLPP4 REEP4 RETREG3 SDHAF4 SLC10A1 SLC10A6 SLC16A2 SLC35H1 SLC39A9 SLC60A2 SLC71A2 STOM STX1A SYT1 TMEM139 TMEM237 TMEM35A TMEM41A TMEM86B
Entrez ID		57549	80777
HPRD ID		10001	13106
Ensembl ID		ENSG00000085552	ENSG00000103018
Uniprot IDs		Q9P2J2	O43169
PDB IDs		1V5J	3NER
Enriched GO Terms of Interacting Partners?		Nitric-oxide Synthase Complex Nitrite Reductase (NO-forming) Activity Ribosome-associated Ubiquitin-dependent Protein Catabolic Process RQC-trigger Complex Guanylate Kinase-associated Protein Clustering Vocal Learning Negative Regulation Of Cell Volume Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Regulation Of Synapse Structural Plasticity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Observational Learning Striatal Medium Spiny Neuron Differentiation Cardiac Ventricle Development DNA Alkylation Repair Positive Regulation Of Glutamate Receptor Signaling Pathway Postsynaptic Specialization Assembly GABAergic Neuron Differentiation Regulation Of Glutamate Receptor Signaling Pathway Neurotransmitter-gated Ion Channel Clustering DNA Repair Complex Auditory Behavior Regulation Of Long-term Synaptic Depression Mechanosensory Behavior Dendritic Spine Morphogenesis Postsynaptic Density Organization Nitric Oxide Biosynthetic Process Brain Morphogenesis Vocalization Behavior Positive Regulation Of Long-term Synaptic Potentiation K63-linked Polyubiquitin Modification-dependent Protein Binding Postsynaptic Specialization Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cardiac Conduction	Membrane
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