PSMD8 and PVR

		PSMD8	PVR
Description		proteasome 26S subunit, non-ATPase 8	PVR cell adhesion molecule
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Lid Subcomplex Proteasome Accessory Complex Protein-containing Complex	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane
	Molecular Function	Protein Binding	Virus Receptor Activity Protein Binding Signaling Receptor Activity Receptor Ligand Activity Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity
	Biological Process	Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Natural Killer Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Nectin/Necl trans heterodimerization
Drugs			Sphingosine Myristic acid
Diseases
GWAS		HDL cholesterol levels ( 32203549)	Alzheimer's disease ( 24755620) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Mean platelet volume ( 27863252 32888494) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Platelet distribution width ( 32888494)
Interacting Genes		10 interacting genes: GLP1R GSK3A GSK3B MTNR1B PRDX6 SHC3 SMAD2 SMAD9 UBC UCHL5	68 interacting genes: ADIPOQ ANKRD46 AP1M2 AQP10 BRICD5 C3orf52 CD226 CD47 CD96 CLDN19 CTXN3 CYB561A3 CYSRT1 DYNLT1 DYNLT3 EBP EDDM3B GPRC5D HHATL HOXA1 INSIG2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-1 KRTAP3-3 KRTAP6-3 KRTAP9-3 MFSD11 NBPF19 NECTIN1 NECTIN3 NINJ1 NINJ2 NOTCH2NLA OLFM4 PGA4 PLA2G3 PLP2 PLPP6 RUSF1 SCD SLC30A2 SLC35B4 SLC41A2 SMIM1 SNAP47 SYS1 TAS2R19 TIGIT TM6SF2 TMBIM6 TMEM147 TMEM229B TMEM54 TMEM65 TMEM79 TSPO VAMP5 VTN WNK1 ZDHHC15 ZDHHC22 ZFPL1 ZFTRAF1
Entrez ID		5714	5817
HPRD ID		10171	01434
Ensembl ID		ENSG00000099341	ENSG00000073008
Uniprot IDs		P48556 V9HW09	A0A0A0MSA9 A0A0C4DG49 A8K4I1 P15151
PDB IDs		5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q	1DGI 1NN8 3EPC 3EPD 3EPF 3J8F 3J9F 3UDW 3URO 4FQP 6ARQ 6ISC 6O3O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Glycogen (starch) Synthase Activity Tau Protein Binding Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cellular Response To Interleukin-3 SMAD Protein Complex Regulation Of Type B Pancreatic Cell Development Heteromeric SMAD Protein Complex Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Beta-catenin Destruction Complex Protein Kinase A Catalytic Subunit Binding I-SMAD Binding Tau-protein Kinase Activity Ubiquitin Protein Ligase Binding Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway SMAD Protein Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Viral Protein Processing Positive Regulation Of Mitochondrial Membrane Permeability Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Membrane Permeability Negative Regulation Of Catalytic Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Glycogen Metabolic Process Negative Regulation Of Multicellular Organismal Process Glucagon-like Peptide 1 Receptor Activity Negative Regulation Of UDP-glucose Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Oxidized DNA Binding Regulation Of Proteasomal Protein Catabolic Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of RNA Metabolic Process Glycogen Metabolic Process Regulation Of Mitochondrial Membrane Permeability Excitatory Postsynaptic Potential Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Superior Temporal Gyrus Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Homomeric SMAD Protein Complex Susceptibility To T Cell Mediated Cytotoxicity Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of Protein ADP-ribosylation	Keratin Filament Intermediate Filament Apical Junction Complex Membrane Cell Adhesion Mediator Activity Establishment Of Protein Localization To Membrane Identical Protein Binding Membrane Destabilizing Activity Regulation Of Natural Killer Cell Mediated Immunity Cell-cell Contact Zone Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cochlea Morphogenesis Regeneration Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Protein Binding Cell Adhesion Positive Regulation Of Mast Cell Activation Steroid Biosynthetic Process Cholesterol Biosynthetic Process
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