ATP13A1 and SYPL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATP13A1	SYPL2
Description		ATPase 13A1	synaptophysin like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Synaptic Vesicle Membrane Synaptic Vesicle Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ABC-type Manganese Transporter Activity P-type Ion Transporter Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Metal Ion Binding P-type Transmembrane Transporter Activity Membrane Protein Dislocase Activity	Protein Binding
	Biological Process	Intracellular Calcium Ion Homeostasis Protein Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Manganese Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Extraction Of Mislocalized Protein From ER Membrane	Intracellular Calcium Ion Homeostasis Heart Development Substantia Nigra Development T-tubule Organization
Pathways		Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Serum alkaline phosphatase levels ( 33339817) Toenail selenium levels ( 25343990) White blood cell count ( 32888494)	Body mass index ( 29273807) Chronic kidney disease ( 20383146) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Estimated glomerular filtration rate ( 31015462 31152163) Glomerular filtration rate (creatinine) ( 26831199 28452372) Major depressive disorder ( 20125088)
Interacting Genes		37 interacting genes: AGTR1 APPBP2 AQP6 ARHGEF5 BIK BUD31 CBARP CXCR2 CYB5R3 EBP ELOVL4 ERGIC3 FAM209A FFAR2 GLP1R GPR42 KMT2E MANBAL MMD RNASEK RUNX1 SCN3B SLC10A1 SLC10A6 SLC16A13 SLC30A2 SLC30A8 SLC35H1 SLC71A2 SNCA SYPL2 TLCD4 TMBIM6 TMEM14B TMEM237 UNC93A VMA21	7 interacting genes: ATP13A1 GET3 PLLP SLC38A7 SLC41A1 SNCA YIPF2
Entrez ID		57130	284612
HPRD ID		12501	17478
Ensembl ID		ENSG00000105726	ENSG00000143028
Uniprot IDs		Q9HD20	B4DYR7 Q5VXT5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Chemical Homeostasis Bile Acid:sodium Symporter Activity Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Zinc:proton Antiporter Activity Protein Binding Intracellular Monoatomic Cation Homeostasis Zinc Ion Import Into Organelle Intracellular Monoatomic Ion Homeostasis Plasma Membrane Homeostatic Process	Response To Magnesium Ion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Monoatomic Ion Transport L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Inorganic Ion Homeostasis Monoatomic Ion Homeostasis Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Monoatomic Cation Homeostasis Regulation Of Transcytosis Magnesium:sodium Antiporter Activity GET Complex Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Asparagine Transport L-asparagine Transmembrane Transporter Activity P-type Transmembrane Transporter Activity Metal Ion Transport Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Compact Myelin P-type Ion Transporter Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Cellular Response To Metal Ion Dopamine Uptake Involved In Synaptic Transmission Sodium Ion Transport Intracellular Magnesium Ion Homeostasis Cellular Response To Magnesium Ion Monoatomic Cation Transport Establishment Of Protein Localization To Membrane Regulation Of Chaperone-mediated Autophagy Response To Iron(II) Ion Calcium Ion Homeostasis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Oxidative Phosphorylation Glutamine Transport L-glutamine Transmembrane Transporter Activity Golgi Trans Cisterna Inorganic Cation Transmembrane Transporter Activity
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