CASS4 and CDC42EP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CASS4	CDC42EP2
Description		Cas scaffold protein family member 4	CDC42 effector protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Anchoring Junction	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Endomembrane System Microtubule Cytoskeleton Membrane Phagocytic Vesicle
	Molecular Function	Protein Binding Protein Tyrosine Kinase Binding	Opioid Peptide Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Actin Filament Organization Rho Protein Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Type II Interferon
Pathways			MAPK6/MAPK4 signaling CDC42 GTPase cycle RHOQ GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Cognitive decline (age-related) ( 28078323) Family history of Alzheimer's disease ( 30617256) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Refractive astigmatism ( 25367360)	Acne (severe) ( 24927181) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494)
Interacting Genes		5 interacting genes: ANKS1B CDC42EP2 FHL3 HSF2BP ZYX	11 interacting genes: ARHGAP26 CASS4 CDC42 COX5B NEDD9 NME7 PICK1 RHOQ SEPTIN6 SEPTIN7 SNCA
Entrez ID		57091	10435
HPRD ID		09842	09363
Ensembl ID		ENSG00000087589	ENSG00000149798
Uniprot IDs		B4DII4 Q9NQ75	O14613
PDB IDs		2CRE
Enriched GO Terms of Interacting Partners?		Organelle Organization Actin Filament-based Process Actin Cytoskeleton Organization Stress Fiber Phagocytic Vesicle Cellular Response To Type II Interferon Response To Type II Interferon Opioid Peptide Activity Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Female Meiosis I	Cytoskeleton Spindle Regulation Of Cytoskeleton Organization GBD Domain Binding Regulation Of Organelle Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Substrate Adhesion-dependent Cell Spreading Sperm Annulus Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Cellular Component Organization Septin Ring Septin Complex GTPase Activity Cell Division Site Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly GTP Binding Cell Projection Positive Regulation Of Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Phospholipid Binding Positive Regulation Of Cell-substrate Adhesion Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Synaptic Vesicle GTP Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Focal Adhesion Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Endocytosis Positive Regulation Of Filopodium Assembly Monoamine Transport Midbody Dendritic Spine Organization Supramolecular Fiber Organization Molecular Adaptor Activity Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Organization Organelle Organization Motile Cilium Protein Tyrosine Kinase Binding Regulation Of Cell-substrate Adhesion Cilium Neuron Projection Organization Cell Projection Organization Postsynapse Organization Regulation Of Cell Projection Assembly Regulation Of Filopodium Assembly Receptor Clustering Cleavage Furrow Actin Filament Organization
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