KIF15 and MKI67

Number of citations: 0 (PubMedID 10878014)
Data Source: HPRD (two hybrid, in vivo)

		KIF15	MKI67
Name		kinesin family member 15	marker of proliferation Ki-67
Structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Kinesin Complex Plus-end Kinesin Complex Microtubule Membrane	Condensed Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Membrane
	Molecular Function	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity	Nucleotide Binding DNA Binding RNA Binding Protein Binding ATP Binding Molecular Condensate Scaffold Activity
	Biological Process	Mitotic Cell Cycle Microtubule-based Movement Centrosome Separation Mitotic Spindle Assembly	Chromosome Segregation Regulation Of Mitotic Nuclear Division Cell Population Proliferation Regulation Of Chromatin Organization
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins	None
GWAS		Acne (severe) ( 24927181 ) Bipolar disorder ( 31043756 ) Bone mineral density (hip) ( 30172743 ) Face memory ( 31596458 ) Idiopathic pulmonary fibrosis ( 31710517 ) Pulse pressure ( 30224653 30578418 ) Sepsis (hospital admission) ( 32592749 ) Severe influenza A (H1N1) infection ( 26379185 )	Alzheimer's disease in APOE e4- carriers ( 25778476 ) Drug experimentation measurement ( 30718321 ) Lead levels ( 26025379 ) Select biomarker traits ( 17903293 ) Suicide attempt severity in mood disorders ( 33783297 ) Triglyceride levels x loop diuretics use interaction ( 31806883 )
Novel Interactors		None recorded	1 novel interactors: DRD4
Interacting Genes		6 interacting genes: AR CEP126 CHD3 MAP1LC3A MKI67 VIM	18 interacting genes: CBX3 CBX5 CDC20 CDH1 CDK1 CEBPA ECPAS HINFP KIF15 NIFK PPP1CA PRKCB PTEN SMN1 SUMO2 TK1 TRIM55 TRIM63
Entrez ID		56992	4288
HPRD ID		10037	08902
Ensembl ID		ENSG00000163808	ENSG00000148773
Uniprot IDs		C9JKA9 Q9NS87	P46013
PDB IDs		4BN2 6ZPH 6ZPI 7RYP	1R21 2AFF 5J28
GO Terms Enriched among Interactors		Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Organelle Organization Prostate Induction Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Molecular Condensate Scaffold Activity Male Somatic Sex Determination Organelle Assembly Positive Regulation Of Integrin Biosynthetic Process Spindle Organization Cytoskeleton Cellular Response To Oxygen-glucose Deprivation Androgen Binding Transcription Cis-regulatory Region Binding RNA Polymerase II General Transcription Initiation Factor Binding Lateral Sprouting From An Epithelium Cellular Response To Testosterone Stimulus Molecular Adaptor Activity Regulation Of Prostatic Bud Formation Cellular Response To Oxygen-containing Compound Prostate Gland Growth Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Differentiation Involved In Prostate Gland Development MAPK Cascade Cytoskeleton Organization Lens Fiber Cell Development Keratin Filament Binding Cellular Response To Muramyl Dipeptide Bergmann Glial Cell Differentiation Response To Iron(II) Ion Cellular Response To Nitrogen Starvation Leydig Cell Differentiation Estrogen Response Element Binding Response To Oxygen-glucose Deprivation Genitalia Morphogenesis Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Autolysosome Male Sex Determination Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Phosphatidylethanolamine Binding Morphogenesis Of An Epithelial Fold	DNA Synthesis Involved In Mitotic DNA Replication Chromatin Binding Rhythmic Process Thymidine Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Thymidine Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleoplasm Negative Regulation Of Cell Cycle Chromosome, Telomeric Region Regulation Of Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex Binding Identical Protein Binding Macromolecule Metabolic Process Mitotic Nuclear Membrane Disassembly Positive Regulation Of Proteolysis Ubiquitin Ligase Activator Activity Pyrimidine Nucleoside Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Postsynapse Spindle Nuclear Membrane Disassembly Cellular Response To Lithium Ion Response To Stress Membrane Disassembly Spindle Assembly Response To Lithium Ion Protein Modification Process Negative Regulation Of Cell Cycle Process PML Body Nucleus Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Primary Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Histone Deacetylase Binding Regulation Of Generation Of Precursor Metabolites And Energy Response To Glucocorticoid Response To Metal Ion Presynaptic Cytosol Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly Pericentric Heterochromatin Mitotic Cell Cycle Phase Transition Centrosome Macromolecule Biosynthetic Process Response To Corticosteroid Regulation Of Nucleobase-containing Compound Metabolic Process