PSMB10 and PSMB8

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical, two hybrid)

		PSMB10	PSMB8
Description		proteasome 20S subunit beta 10	proteasome 20S subunit beta 8
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Spermatoproteasome Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome Spermatoproteasome Complex
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Cell Morphogenesis Proteolysis Humoral Immune Response T Cell Proliferation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process	Immune System Process Proteolysis Antigen Processing And Presentation Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Proteolysis Involved In Protein Catabolic Process
Pathways		ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation	ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Interferon alpha/beta signaling Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs		Carfilzomib	Carfilzomib
Diseases
GWAS		Crohn's disease ( 22412388) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) IgA nephropathy ( 25305756 32912934) Nephropathy ( 21399633)
Interacting Genes		11 interacting genes: ANXA7 CCNDBP1 CRX MEOX2 POMP PSMA1 PSMA2 PSMA3 PSMB8 PSMB9 PTN	22 interacting genes: ABCB1 DUSP23 GNPNAT1 INCA1 LSM1 MEOX2 NFKBID PFDN5 POLR2G POMP PSMB10 REL SNX5 TAP1 TAP2 TENT5B TRAF3 TRIP13 UBAP2 WWOX YJEFN3 ZMYND12
Entrez ID		5699	5696
HPRD ID		01465	01515
Ensembl ID		ENSG00000205220	ENSG00000204264
Uniprot IDs		P40306	P28062
PDB IDs		6AVO 6E5B 6HV3 6HV4 6HV5 6HV7 6HVA 6HVR 6HVS 6HVT 6HVU 6HVV 6HVW 7AWE 7B12 9FSV	5L5A 5L5B 5L5D 5L5E 5L5F 5L5H 5L5I 5L5J 5L5O 5L5P 5L5Q 5L5R 5L5S 5L5T 5L5U 5L5V 5LTT 5M2B 6AVO 6E5B 7AWE 7B12
Enriched GO Terms of Interacting Partners?		Proteasome Core Complex Proteasome Complex Proteasome Core Complex, Alpha-subunit Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Spermatoproteasome Complex Proteasomal Protein Catabolic Process Threonine-type Endopeptidase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome Core Complex, Beta-subunit Complex Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Nucleus Macromolecule Catabolic Process Proteolysis Catabolic Process Extracellular Exosome Dendrite Regeneration Endopeptidase Activity Ossification Involved In Bone Remodeling Nuclear Speck	Peptide Transmembrane Transporter Activity ABC-type Peptide Antigen Transporter Activity TAP Complex ABC-type Peptide Transporter Activity TAP1 Binding Cytosol To Endoplasmic Reticulum Transport ABC-type Transporter Activity MHC Class Ib Protein Binding MHC Protein Binding MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex P-body Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I RNA Polymerase III Assembly RNA Polymerase I Assembly Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Amide Transport Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Endogenous Antigen Tapasin Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Macropinocytic Cup Glucosamine 6-phosphate N-acetyltransferase Activity ATP Hydrolysis Activity
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