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PSMB2 and DDX49
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
PSMB2
DDX49
Gene Name
proteasome (prosome, macropain) subunit, beta type, 2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Core Complex
Membrane
Extracellular Vesicular Exosome
Molecular Function
Threonine-type Endopeptidase Activity
Protein Binding
Helicase Activity
ATP Binding
Poly(A) RNA Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Response To Organonitrogen Compound
Gene Expression
Response To Organic Cyclic Compound
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Metabolic Process
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
DDX49
GPX2
KCTD9
KRT13
PLK1
PSMA1
PSMB3
2 interactors:
HAP1
PSMB2
Entrez ID
5690
54555
HPRD ID
03708
10864
Ensembl ID
ENSG00000105671
Uniprot IDs
B7Z478
P49721
Q9Y6V7
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cellular Protein Catabolic Process
DNA Damage Checkpoint
Mitotic Cell Cycle Checkpoint
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Cell Cycle Checkpoint
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle
Positive Regulation Of Proteolysis
Negative Regulation Of Transferase Activity
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Regulation Of Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cellular Amino Acid Metabolic Process
Regulation Of Mitotic Cell Cycle
Mitotic G1 DNA Damage Checkpoint
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Positive Regulation Of Cell Cycle Arrest
Negative Regulation Of Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Cell Cycle Process
Regulation Of Cellular Ketone Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Signal Transduction In Response To DNA Damage
Modification-dependent Protein Catabolic Process
Mitotic DNA Damage Checkpoint
Regulation Of Cell Cycle Arrest
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Neurotrophin Production
Positive Regulation Of Nonmotile Primary Cilium Assembly
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle
Regulation Of Organelle Transport Along Microtubule
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Positive Regulation Of Cilium Assembly
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Hypothalamus Cell Differentiation
Negative Regulation Of Beta-amyloid Formation
Retrograde Axon Cargo Transport
Mitotic Cell Cycle
Negative Regulation Of Amyloid Precursor Protein Catabolic Process
Regulation Of Microtubule-based Movement
Positive Regulation Of Synaptic Transmission, GABAergic
Response To Organonitrogen Compound
Cellular Response To DNA Damage Stimulus
Cellular Macromolecule Catabolic Process
Nucleotide-excision Repair, DNA Gap Filling
Negative Regulation Of Smooth Muscle Cell Migration
Response To Organic Cyclic Compound
DNA Demethylation
Negative Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Telomere Maintenance Via Semi-conservative Replication
Regulation Of Beta-amyloid Formation
Regulation Of Cilium Assembly
Nuclear DNA Replication
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Amyloid Precursor Protein Catabolic Process
Telomere Maintenance Via Recombination
Cell Cycle Process
Positive Regulation Of ERBB Signaling Pathway
Positive Regulation Of Calcium Ion Transmembrane Transporter Activity
Hypothalamus Development
Positive Regulation Of Organelle Assembly
Positive Regulation Of Cell Cycle G1/S Phase Transition
Anterograde Axon Cargo Transport
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Cation Channel Activity
Tagcloud
?
20s
abstaining
accumulated
affecting
antagonizes
apigenin
biochemistry
bortezomib
chymotrypsin
depolarization
desired
deubiquitinase
e6ap
fda
flavonoid
mechanistically
pc
preferentially
proteasomal
proteasome
psma5
psmb1
psmb5
selectively
subtle
trihydroxyflavone
trypsin
ubiquitinated
usp14
Tagcloud (Difference)
?
20s
abstaining
accumulated
affecting
antagonizes
apigenin
biochemistry
bortezomib
chymotrypsin
depolarization
desired
deubiquitinase
e6ap
fda
flavonoid
mechanistically
pc
preferentially
proteasomal
proteasome
psma5
psmb1
psmb5
selectively
subtle
trihydroxyflavone
trypsin
ubiquitinated
usp14
Tagcloud (Intersection)
?