PSMB2 and UBD

Number of citations of the paper that reports this interaction (PubMedID 37012049)
67

Data Source:
BioGRID (pull down)

		PSMB2	UBD
Description		proteasome 20S subunit beta 2	ubiquitin like modifier D
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Membrane Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Aggresome
	Molecular Function	Protein Binding	Protein Binding Proteasome Binding
	Biological Process	Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Response To Stress Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To Type II Interferon Response To Tumor Necrosis Factor Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Aggresome Assembly Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Neddylation
Drugs		(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Carfilzomib
Diseases
GWAS		Type 1 diabetes ( 34012112)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Fish- and plant-related diet ( 32066663) Height ( 25429064) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		16 interacting genes: AXIN2 CEBPA DDX49 GPX2 HSPB1 INCA1 KCTD9 KRT13 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 PLK1 PSMA1 PSMB3 UBD	29 interacting genes: MAD2L1 NUB1 OTUB1 PDE9A PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMD2 PSMD4 SAE1 SRPK1 SRPK2 TGFBR1 UBA2 UBA6 UBE2D2 UBE2Z USP16
Entrez ID		5690	10537
HPRD ID		03708	09354
Ensembl ID		ENSG00000126067	ENSG00000213886
Uniprot IDs		A0A087WVV1 A0A140VJS6 B7Z478 P49721	A0A1U9X8S6 O15205
PDB IDs		4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ 7AWE 7B12 7LXV 7NAN 7NAO 7NAP 7NAQ 7NHT 7PG9 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7V5G 7V5M 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8BZL 8CVR 8CVS 8CVT 8CXB 8QYM 8QYN 8QYO 8QYS 8QZ9 8TM4 8TM5 8TM6 8UD9 8YIX 8YIY 8YIZ 9E8G 9E8O 9E8Q 9HMN	2MBE 6GF1 6GF2 7PYV 9E8O
Enriched GO Terms of Interacting Partners?		Intermediate Filament Proteasome Complex Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Proteasome Core Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cytosol Positive Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process Response To Dexamethasone Negative Regulation Of Protein Kinase C Signaling Regulation Of RRNA Stability	Proteasome Core Complex Proteasome Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Proteasome Core Complex, Alpha-subunit Complex Protein Catabolic Process Protein Metabolic Process Proteasome Core Complex, Beta-subunit Complex Nucleoplasm Catabolic Process Macromolecule Metabolic Process Nucleus Cytosol Extracellular Exosome Threonine-type Endopeptidase Activity Ubiquitin-like Modifier Activating Enzyme Activity Secretory Granule Lumen Ficolin-1-rich Granule Lumen SUMO Activating Enzyme Activity SUMO Activating Enzyme Complex Cytoplasm Ubiquitin Activating Enzyme Activity Endopeptidase Activity Small Protein Activating Enzyme Binding Protein Modification Process Post-translational Protein Modification Proteasome Regulatory Particle, Base Subcomplex Positive Regulation Of Protein Sumoylation Proteasome Accessory Complex P-body Regulation Of Protein Sumoylation Regulation Of Post-translational Protein Modification Peptidase Activity Protein Modification By Small Protein Conjugation Protein Binding Positive Regulation Of Viral Genome Replication Negative Regulation Of Inflammatory Response To Antigenic Stimulus Ubiquitin Conjugating Enzyme Activity Lipopolysaccharide Binding Purine Ribonucleoside Triphosphate Binding Positive Regulation Of Ribosome Biogenesis FAT10 Activating Enzyme Activity Peptidyl-serine Phosphorylation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication
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