DEFB103B and CCR6

Number of citations of the paper that reports this interaction (PMID 11714836)
43

Data Source:
HPRD (in vitro, in vivo)

		DEFB103B	CCR6
Gene Name		defensin, beta 103B	chemokine (C-C motif) receptor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Golgi Lumen	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function		Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity
	Biological Process	Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria Defense Response To Bacterium Innate Immune Response	Dendritic Cell Chemotaxis Movement Of Cell Or Subcellular Component Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Innate Immune Response Chemokine-mediated Signaling Pathway
Pathways		Beta defensins Defensins Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Beta defensins Defensins G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Innate Immune System
Drugs
Diseases
GWAS			Crohn's disease ( 18587394 20570966 21102463) Inflammatory bowel disease ( 23128233) Rheumatoid arthritis ( 20453841 20453842) Vitiligo ( 20526339)
Protein-Protein Interactions		1 interactors: CCR6	4 interactors: CCL20 DEFB1 DEFB103B DEFB4A
Entrez ID		55894	1235
HPRD ID		05968	03498
Ensembl ID			ENSG00000112486
Uniprot IDs		P81534	P51684
PDB IDs		1KJ6
Enriched GO Terms of Interacting Partners?		Dendritic Cell Chemotaxis Dendritic Cell Migration Cellular Defense Response Chemokine-mediated Signaling Pathway Leukocyte Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Chemotaxis Cytosolic Calcium Ion Homeostasis	Defense Response To Bacterium Response To Bacterium Response To Other Organism Response To Biotic Stimulus Immune Response Defense Response Response To External Stimulus Chemotaxis Immune System Process Innate Immune Response Positive Regulation Of Interleukin-1 Alpha Biosynthetic Process Response To Stress Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria Locomotion Positive Regulation Of Antimicrobial Humoral Response Regulation Of Antimicrobial Humoral Response Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Defense Response To Bacterium Inflammatory Response Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cellular Response To Lipoteichoic Acid Positive Regulation Of Humoral Immune Response Innate Immune Response In Mucosa Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Antibacterial Humoral Response Antimicrobial Humoral Response Regulation Of Lymphocyte Migration Mucosal Immune Response Positive Regulation Of Interleukin-1 Production Response To Testosterone Response To Lipid Positive Regulation Of Immune System Process Regulation Of Humoral Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process Acute Inflammatory Response G-protein Coupled Receptor Signaling Pathway Response To Stimulus Positive Regulation Of Leukocyte Migration Regulation Of Immune System Process Regulation Of Cytokine Biosynthetic Process Regulation Of Leukocyte Migration Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Cell Chemotaxis
Tagcloud ?			confounding conservation corresponded cxcr3 elicit eliminating epitopes hc hcs hyperconserved intragenus latent ltbi mtb mycobacteria naturally nonexposed nontuberculous ntm ntms opposite phenotypically reactivity recognize responded translated true unbiased unexpectedly
Tagcloud (Difference) ?			confounding conservation corresponded cxcr3 elicit eliminating epitopes hc hcs hyperconserved intragenus latent ltbi mtb mycobacteria naturally nonexposed nontuberculous ntm ntms opposite phenotypically reactivity recognize responded translated true unbiased unexpectedly
Tagcloud (Intersection) ?