WWC3 and WWC1

Number of citations of the paper that reports this interaction (PubMedID 24682284)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		WWC3	WWC1
Description		WWC family member 3	WW and C2 domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Kinase Binding Signaling Adaptor Activity Molecular Adaptor Activity	Transcription Coactivator Activity Protein Binding Kinase Binding Signaling Adaptor Activity Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Cell Migration Hippo Signaling Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling Negative Regulation Of Organ Growth	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Cell Migration Establishment Of Cell Polarity Hippo Signaling Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Negative Regulation Of Organ Growth
Pathways			Signaling by Hippo NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Mild influenza (H1N1) infection ( 26379185) Prostate cancer ( 23535732)	Adult body size ( 32376654) Cerebellum cortex volume ( 31530798) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Epithelial ovarian cancer ( 31469419) Mental health study participation (provided email address) ( 31263887) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Periodontal microbiota ( 22699663) Regular attendance at a religious group ( 29970889) Type 2 diabetes nephropathy including microalbuminuria ( 30566433)
Interacting Genes		5 interacting genes: APP CIP2A WBP2 WWC1 WWC2	16 interacting genes: AIFM1 CDC5L CDC73 DDN FAM219A FEZ1 FEZ2 H3C1 KIAA0513 LRIF1 MAPK6 PRKCZ TNIK UBC WWC2 WWC3
Entrez ID		55841	23286
HPRD ID		11136	10033
Ensembl ID		ENSG00000047644	ENSG00000113645
Uniprot IDs		Q9ULE0	Q8IX03
PDB IDs			2Z0U 6FB4 6FD0 6FJC 6FJD
Enriched GO Terms of Interacting Partners?		Hippo Signaling Negative Regulation Of Hippo Signaling Negative Regulation Of Organ Growth Regulation Of Developmental Growth Regulation Of Hippo Signaling Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Organ Growth Signaling Adaptor Activity Negative Regulation Of Developmental Growth Kinase Binding Regulation Of Growth Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Regulation Of Intracellular Signal Transduction Positive Regulation Of G Protein-coupled Receptor Internalization Broken Chromosome Clustering Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Molecular Adaptor Activity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission Negative Regulation Of Transcription By RNA Polymerase II NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Negative Regulation Of Growth Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Autophagosome Assembly
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