PRKAR2B and MT1H

Data Source: HiPPIP (Novel)

		PRKAR2B	MT1H
Name		protein kinase cAMP-dependent type II regulatory subunit beta	metallothionein 1H
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Fatty Acid Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Negative Regulation Of CAMP/PKA Signal Transduction	Intracellular Zinc Ion Homeostasis Detoxification Of Copper Ion Negative Regulation Of Growth Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Metallothioneins bind metals
Drugs		Cyclic adenosine monophosphate	Silver
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998 ) Bladder cancer (smoking interaction) ( 24662972 ) Blood urea nitrogen levels ( 31152163 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 28552196 ) Manganese levels ( 26025379 ) Response to antipsychotic treatment ( 20195266 ) Triglyceride levels ( 32203549 )	Gambling ( 22780124 )
Novel Interactors		8 novel interactors: ABCB4 CBR1 LAMB1 LRCH4 MT1H RAP2B RPL30 TFR2	1 novel interactors: PRKAR2B
Interacting Genes		17 interacting genes: AKAP1 AKAP10 AKAP11 AKAP14 AKAP19 AKAP4 AKAP5 AKAP9 CFAP91 ECM1 GNAI3 KIF5B LASP1 NBEA OGT PAK1IP1 TAF12	3 interacting genes: RNF181 SERPINB5 SPINK7
Entrez ID		5577	4496
HPRD ID		01486	01128
Ensembl ID		ENSG00000005249	ENSG00000205358
Uniprot IDs		B3KY43 P31323	A0A140VJP7 P80294
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Negative Regulation Of Adenylate Cyclase Activity CAMP-dependent Protein Kinase Complex	Serine-type Endopeptidase Inhibitor Activity Response To Antipsychotic Drug Prostate Gland Morphogenesis CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity