PRKAR2B and RPL30

		PRKAR2B	RPL30
Description		protein kinase cAMP-dependent type II regulatory subunit beta	ribosomal protein L30
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Fatty Acid Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Negative Regulation Of CAMP/PKA Signal Transduction	Cytoplasmic Translation Translation Killing Of Cells Of Another Organism Defense Response To Gram-negative Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Cyclic adenosine monophosphate
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)	Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: AKAP1 AKAP10 AKAP11 AKAP14 AKAP19 AKAP4 AKAP5 AKAP9 CFAP91 ECM1 GNAI3 KIF5B LASP1 NBEA OGT PAK1IP1 TAF12	16 interacting genes: APP CASP2 DUX4 ERCC6 FAM120B G0S2 IL7R MAP2K7 MAP3K14 NEDD4L NFKB2 OAS1 OGT PTEN USP40 ZFAND2A
Entrez ID		5577	6156
HPRD ID		01486	01595
Ensembl ID		ENSG00000005249	ENSG00000156482
Uniprot IDs		B3KY43 P31323	P62888
PDB IDs			3VI6 4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Negative Regulation Of Adenylate Cyclase Activity CAMP-dependent Protein Kinase Complex	Intracellular Signal Transduction Positive Regulation Of Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Rhythmic Process Cytosol Enzyme Binding Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Proteolysis Positive Regulation Of Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Catabolic Process Molecular Function Activator Activity Positive Regulation Of Signal Transduction Dendritic Spine Reproductive Behavior Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Peptidyl-serine Phosphorylation Non-canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Hemopoiesis Positive Regulation Of DNA-templated Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Neuron Projection Organization Cellular Developmental Process Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Response To Mechanical Stimulus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Neuron Projection Development Modulation Of Excitatory Postsynaptic Potential
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