CNDP2 and DAPP1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		CNDP2	DAPP1
Description		carnosine dipeptidase 2	dual adaptor of phosphotyrosine and 3-phosphoinositides 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Carboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Dipeptidase Activity Metal Ion Binding Metallodipeptidase Activity	Protein Binding Phospholipid Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Proteolysis	Protein Dephosphorylation Signal Transduction
Pathways		Glutathione synthesis and recycling Paracetamol ADME	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		Refractive error ( 23396134 32231278) Serum metabolite levels ( 33031748)	Red cell distribution width ( 32888494) Stroke ( 32693751)
Interacting Genes		8 interacting genes: CNDP1 CRK DAPP1 FILNC1 NDRG1 OGT STAT3 ZDHHC17	23 interacting genes: BTK CNDP2 ERBB3 FAIM FCHSD2 FXN GSTCD HSD3B7 HSPA1A LCK LYN MAP4K1 MGARP MYLIP PLAGL2 PLCG1 PLCG2 RBP7 RPL23 SRC TM4SF19 TNFAIP1 ZNHIT1
Entrez ID		55748	27071
HPRD ID		09893	05773
Ensembl ID		ENSG00000133313	ENSG00000070190
Uniprot IDs		Q96KP4	J3KNB3 Q9UN19
PDB IDs		4RUH	1FAO 1FB8
Enriched GO Terms of Interacting Partners?		Regulation Of Natural Killer Cell Mediated Immunity Helper T Cell Diapedesis Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Signaling Receptor Binding Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Response To Peptide Hormone Signaling Adaptor Activity Protein Phosphorylated Amino Acid Binding Regulation Of Rac Protein Signal Transduction Positive Regulation Of Signaling Regulation Of Natural Killer Cell Mediated Cytotoxicity Response To Cholecystokinin Regulation Of ATP Metabolic Process Regulation Of Carbohydrate Catabolic Process Chromatin DNA Binding Regulation Of Glycolytic Process Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Phosphatidylinositol-3,4,5-trisphosphate Binding Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of Leukocyte Mediated Cytotoxicity Cerebellar Neuron Development Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Intracellular Signal Transduction Plasma Membrane RNA Sequestering Activity Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Response To Wounding Diapedesis Regulation Of Protein Localization To Membrane Response To Hormone Negative Regulation Of Hydrogen Peroxide Metabolic Process Postsynapse To Nucleus Signaling Pathway Interleukin-11-mediated Signaling Pathway Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway T-helper 17 Type Immune Response Glutamatergic Synapse Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose	Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Phospholipase Activator Activity Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Programmed Cell Death Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phospholipase Binding Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Response To Lipid Immune Response-activating Signaling Pathway Membrane Raft Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Fc-gamma Receptor Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Histamine Secretion By Mast Cell Positive Regulation Of Immune Response Protein Autophosphorylation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of MAPK Cascade Cellular Response To Lipid Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Developmental Process T Cell Costimulation Positive Regulation Of Immune System Process Histamine Secretion Positive Regulation Of Epithelial Cell Migration Protein Kinase Activity Positive Regulation Of Innate Immune Response Signaling Receptor Activator Activity Release Of Sequestered Calcium Ion Into Cytosol Histamine Transport Negative Regulation Of Sequestering Of Calcium Ion
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