DAPP1 and GSTCD

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		DAPP1	GSTCD
Description		dual adaptor of phosphotyrosine and 3-phosphoinositides 1	glutathione S-transferase C-terminal domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Phospholipid Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding	Molecular_function Protein Binding
	Biological Process	Protein Dephosphorylation Signal Transduction	Biological_process Response To Lipopolysaccharide Respiratory System Development
Pathways		Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		Red cell distribution width ( 32888494) Stroke ( 32693751)	Asthma ( 31959851) Chronic obstructive pulmonary disease ( 28166215) Copper levels ( 26025379) FEV1 ( 30804560) Lung function (FEV1) ( 24023788 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 28166213 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Peak expiratory flow ( 30804560) Post bronchodilator FEV1 ( 26634245) Psoriasis ( 31376382) Pulmonary function ( 20010835 20010834) Pulmonary function (smoking interaction) ( 23284291) Sleep (1/3-day periodicity) ( 33075057)
Interacting Genes		23 interacting genes: BTK CNDP2 ERBB3 FAIM FCHSD2 FXN GSTCD HSD3B7 HSPA1A LCK LYN MAP4K1 MGARP MYLIP PLAGL2 PLCG1 PLCG2 RBP7 RPL23 SRC TM4SF19 TNFAIP1 ZNHIT1	7 interacting genes: CLNK DAPP1 KDM1A PRMT6 STAT3 SUV39H2 TNS4
Entrez ID		27071	79807
HPRD ID		05773	07823
Ensembl ID		ENSG00000070190	ENSG00000138780
Uniprot IDs		J3KNB3 Q9UN19	B7Z8J7 Q8NEC7
PDB IDs		1FAO 1FB8
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Phospholipase Activator Activity Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Programmed Cell Death Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phospholipase Binding Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Response To Lipid Immune Response-activating Signaling Pathway Membrane Raft Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Fc-gamma Receptor Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Histamine Secretion By Mast Cell Positive Regulation Of Immune Response Protein Autophosphorylation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of MAPK Cascade Cellular Response To Lipid Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Developmental Process T Cell Costimulation Positive Regulation Of Immune System Process Histamine Secretion Positive Regulation Of Epithelial Cell Migration Protein Kinase Activity Positive Regulation Of Innate Immune Response Signaling Receptor Activator Activity Release Of Sequestered Calcium Ion Into Cytosol Histamine Transport Negative Regulation Of Sequestering Of Calcium Ion	Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Transcription Regulator Complex Interleukin-10-mediated Signaling Pathway RNA Sequestering Activity Negative Regulation Of Primary MiRNA Processing Cellular Response To Leptin Stimulus Regulation Of Cell Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Postsynapse To Nucleus Signaling Pathway Interleukin-9-mediated Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Interleukin-11-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Protein-containing Complex Retinal Rod Cell Differentiation Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Cellular Response To Interleukin-17 Interleukin-15-mediated Signaling Pathway Negative Regulation Of MiRNA Processing T-helper 17 Type Immune Response Negative Regulation Of Inflammatory Response To Wounding Primary MiRNA Binding DNA-binding Transcription Factor Binding Leptin-mediated Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation CCR5 Chemokine Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3K9 Demethylase Activity Response To Fungicide MRF Binding Histone H3K4 Demethylase Activity Guanine Metabolic Process Protein Demethylase Activity Chromatin Remodeling Telomeric Repeat-containing RNA Binding Regulation Of Signal Transduction By P53 Class Mediator FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Chromatin Organization Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine N-methyltransferase Activity
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