PYDC2 and NLRP2

Number of citations of the paper that reports this interaction (PMID 17178784)
19

Data Source:
HPRD (in vivo, in vitro)

		PYDC2	NLRP2
Gene Name		pyrin domain containing 2	NLR family, pyrin domain containing 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm
	Molecular Function	Protein Binding	Protein Binding ATP Binding Pyrin Domain Binding
	Biological Process		Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interleukin-1 Beta Secretion
Pathways
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		2 interactors: NLRP2 PYCARD	4 interactors: APP CARD8 FAF1 PYDC2
Entrez ID		152138	55655
HPRD ID		19279	14805
Ensembl ID		ENSG00000253548	ENSG00000022556
Uniprot IDs		Q56P42	J3KN39 Q9NX02
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cytokine Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Positive Regulation Of Peptidase Activity Positive Regulation Of Protein Secretion Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Proteolysis Positive Regulation Of Secretion Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Regulation Of Endopeptidase Activity Regulation Of Protein Secretion Regulation Of Peptidase Activity Macropinocytosis Positive Regulation Of Interleukin-6 Secretion Regulation Of Cytokine Production Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Protein Transport Positive Regulation Of Interleukin-8 Secretion Regulation Of Secretion Regulation Of Proteolysis Positive Regulation Of Chemokine Secretion Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Secretion Regulation Of Protein Localization Negative Regulation Of Interferon-beta Production Regulation Of Interleukin-8 Secretion Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Pinocytosis Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T Cell Migration Regulation Of Interleukin-10 Secretion Apoptotic Process Regulation Of T Cell Migration Programmed Cell Death	Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Collateral Sprouting In Absence Of Injury Positive Regulation Of Proteolysis Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cellular Protein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Endopeptidase Activity Axon Choice Point Recognition Cytoplasmic Sequestering Of NF-kappaB Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Neuron Remodeling Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Protein Transport Negative Regulation Of NF-kappaB Import Into Nucleus Cellular Copper Ion Homeostasis Regulation Of Signaling Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Establishment Of Protein Localization Positive Regulation Of Interleukin-1 Secretion Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Kinase Activity Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasmic Sequestering Of Protein Regulation Of Kinase Activity Regulation Of Protein Localization Positive Regulation Of Interleukin-1 Beta Production Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Interleukin-1 Production Mating Behavior
Tagcloud ?			1alpha 1beta adenosine aim2 analogs atp atpgammas benzoylbenzoyl bzatp danger fibrosis immunochemistry inflammasome lipopolysaccharide macrophages monocyte natively nlrc4 nlrp1 nlrp3 nlrp6 p2x7 potentiate primed purinergic salt tetralithium thio triphosphate
Tagcloud (Difference) ?			1alpha 1beta adenosine aim2 analogs atp atpgammas benzoylbenzoyl bzatp danger fibrosis immunochemistry inflammasome lipopolysaccharide macrophages monocyte natively nlrc4 nlrp1 nlrp3 nlrp6 p2x7 potentiate primed purinergic salt tetralithium thio triphosphate
Tagcloud (Intersection) ?