PYDC2

Description		pyrin domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Protein Binding
	Biological Process	Immune System Process Inflammatory Response Negative Regulation Of Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Beta Production Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways
Drugs
Diseases
GWAS		Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		2 interacting genes: NLRP2 PYCARD
Entrez ID		152138
HPRD ID		19279
Ensembl ID		ENSG00000253548
Uniprot IDs		Q56P42
PDB IDs
Enriched GO Terms of Interacting Partners?		Pyrin Domain Binding Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Myosin I Binding NLRP6 Inflammasome Complex Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II AIM2 Inflammasome Complex Myeloid Dendritic Cell Activation Involved In Immune Response Regulation Of Inflammatory Response Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Positive Regulation Of Cytokine Production NLRP1 Inflammasome Complex Interleukin-6 Receptor Binding IkappaB Kinase Complex Macropinocytosis Inflammatory Response Cysteine-type Endopeptidase Activator Activity Pinocytosis Innate Immune Response BMP Receptor Binding Tropomyosin Binding Canonical Inflammasome Complex Negative Regulation Of Interferon-beta Production Defense Response To Symbiont Defense Response To Other Organism Negative Regulation Of Intracellular Signal Transduction Regulation Of Cytokine Production Regulation Of Defense Response Apoptotic Process Regulation Of Antigen Processing And Presentation NLRP3 Inflammasome Complex Assembly Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Release Of Cytochrome C From Mitochondria Programmed Cell Death Cell Death Myeloid Dendritic Cell Activation Positive Regulation Of Activated T Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of T Cell Migration Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Positive Regulation Of Defense Response To Virus By Host Response To Other Organism Canonical Inflammasome Complex Assembly Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Activated T Cell Proliferation
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