SVOP and CYSLTR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SVOP	CYSLTR2
Description		SV2 related protein	cysteinyl leukotriene receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Synaptic Vesicle Basal Plasma Membrane Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse	Plasma Membrane Membrane
	Molecular Function	Protein Binding Transmembrane Transporter Activity	Cysteinyl Leukotriene Receptor Activity G Protein-coupled Receptor Activity Galanin Receptor Activity Leukotriene Receptor Activity Protein Binding
	Biological Process	Xenobiotic Transport Transmembrane Transport	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Leukotriene Signaling Pathway
Pathways			Leukotriene receptors G alpha (q) signalling events G alpha (s) signalling events LTC4-CYSLTR mediated IL4 production
Drugs			Nedocromil Leukotriene C4 Leukotriene D4
Diseases
GWAS			3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		7 interacting genes: CCR2 CLK1 CYSLTR2 FXYD6 GLP1R OGT TAAR1	19 interacting genes: ATP5MC2 DBI ENO1 GNAS GRIK1 HSP90B1 KRTAP1-1 LNX1 MTUS2 NCKIPSD PCDH9 PCMT1 RNASEK RNF144A RTN4 SVOP TTC19 YIPF6 YWHAE
Entrez ID		55530	57105
HPRD ID		13224	09293
Ensembl ID		ENSG00000166111	ENSG00000152207
Uniprot IDs		Q8N4V2	A4ZKH2 Q5KU17 Q9NS75
PDB IDs
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Glucagon-like Peptide 1 Receptor Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cysteinyl Leukotriene Receptor Activity G Protein-coupled Amine Receptor Activity Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Positive Regulation Of Cold-induced Thermogenesis Trace-amine Receptor Activity Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Glucagon Receptor Activity Protein O-acetylglucosaminyltransferase Activity Leukotriene Receptor Activity Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cold-induced Thermogenesis Leukotriene Signaling Pathway CCR2 Chemokine Receptor Binding Positive Regulation Of T Cell Extravasation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Psychosocial Stress Plasma Membrane Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Monocyte Extravasation Monocyte Extravasation Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Hemopoiesis Neutrophil Clearance Carbon Catabolite Regulation Of Transcription Ion Channel Regulator Activity Galanin Receptor Activity Post-translational Protein Targeting To Membrane, Translocation Positive Regulation Of Sodium Ion Export Across Plasma Membrane Regulation Of Transcription By Glucose Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Glutamate Receptor Signaling Pathway	Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway
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