CSF2 and PRG2

Number of citations of the paper that reports this interaction (PubMedID 7727786)
0

Data Source:
HPRD (in vitro)

		CSF2	PRG2
Description		colony stimulating factor 2	proteoglycan 2, pro eosinophil major basic protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex	Extracellular Region Transport Vesicle Extracellular Matrix Cytoplasmic Vesicle Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity	Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding
	Biological Process	Histamine Secretion Embryonic Placenta Development Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Myeloid Cell Differentiation Neutrophil Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Interleukin-23 Production Response To Silicon Dioxide Response To Fluid Shear Stress Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Epithelial Fluid Transport Regulation Of Cell Population Proliferation Myeloid Dendritic Cell Differentiation Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of DNA-templated Transcription Regulation Of Developmental Process Positive Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Dendritic Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Defense Response To Nematode Immune System Process Immune Response Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Defense Response To Bacterium
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling	Neutrophil degranulation
Drugs		KB002	Sargramostim Chymopapain
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Rheumatoid arthritis ( 22446963 24390342 30423114) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Crohn's disease ( 22412388) Glucose homeostasis traits ( 25524916)
Interacting Genes		9 interacting genes: CSF2RA CSF2RB IL3RA KITLG MEOX2 PRG2 S100A6 S100P SDC2	7 interacting genes: AGT AKT1 CHD3 CSF2 PAPPA PRKCZ RBM48
Entrez ID		1437	5553
HPRD ID		00734	09283
Ensembl ID		ENSG00000164400	ENSG00000186652
Uniprot IDs		P04141	P13727
PDB IDs		1CSG 2GMF 4NKQ 4RS1 5C7X 5D70 5D71 5D72 6BFQ 6BFS	1H8U 2BRS 4QXX 7Y5N 8HGG 9DKZ
Enriched GO Terms of Interacting Partners?		Interleukin-3 Receptor Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Regulation Of Macrophage Cytokine Production Cytokine Receptor Activity External Side Of Plasma Membrane Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Extracellular Matrix Signaling Receptor Activity Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Cytokine Binding Positive Regulation Of Bone Mineralization Translation Termination Factor Activity Cytoplasmic Translational Termination Regulation Of Production Of Molecular Mediator Of Immune Response Leukocyte Apoptotic Process Positive Regulation Of Biomineral Tissue Development Immune System Process Positive Regulation Of Ossification Neural Crest Cell Migration Mesenchymal Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Cell Population Proliferation	Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Differentiation Positive Regulation Of Steroid Metabolic Process Response To Fluid Shear Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cholesterol Metabolic Process Response To Peptide Hormone Positive Regulation Of Cell Differentiation Regulation Of Sodium Ion Transport Regulation Of Apoptotic Signaling Pathway Regulation Of TRNA Methylation Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Cytokine Production Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Membrane Potential Response To Hormone Renin-angiotensin Regulation Of Aldosterone Production Negative Regulation Of Signaling Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Growth Factor Activity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Developmental Process Positive Regulation Of Endothelial Cell Migration Regulation Of Lipid Transport Positive Regulation Of Membrane Hyperpolarization Regulation Of Programmed Cell Death Positive Regulation Of Locomotion Positive Regulation Of Lipid Metabolic Process Response To Muscle Activity Involved In Regulation Of Muscle Adaptation G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Regulation Of Renal Output By Angiotensin Negative Regulation Of Cell Communication Positive Regulation Of Macromolecule Biosynthetic Process Type 2 Angiotensin Receptor Binding Negative Regulation Of Transmembrane Transport Regulation Of Steroid Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Organelle Assembly
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