PRB3 and SH3YL1

Number of citations: 82 (PubMedID 36949045)
Data Source: BioGRID (two hybrid)

		PRB3	SH3YL1
Name		proline rich protein BstNI subfamily 3	SH3 and SYLF domain containing 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Ruffle Membrane
	Molecular Function	Protein Binding	Protein Binding Phosphatase Binding Phosphatidylinositol Binding
	Biological Process	Defense Response To Gram-negative Bacterium	Phosphatidylinositol Biosynthetic Process Regulation Of Ruffle Assembly
GWAS		No GWAS studies recorded	A body shape index ( 34021172 ) Apolipoprotein A1 levels ( 32203549 ) Blood urea nitrogen levels ( 31152163 ) Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Estimated glomerular filtration rate ( 31152163 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels ( 32203549 ) Large artery stroke ( 28265093 ) Mitochondrial DNA levels ( 25240745 ) Night sleep phenotypes ( 27126917 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		9 interacting genes: ALB GET3 PBX3 PPIF SGTB SH3GL1 SH3RF1 SH3YL1 TBRG4	11 interacting genes: AR ERRFI1 GFAP HELZ KHDRBS1 PRB3 SH3D19 SYNJ1 VIM VPS37B ZBTB7B
Entrez ID		5544	26751
HPRD ID		01352	15336
Ensembl ID		ENSG00000197870	ENSG00000035115
Uniprot IDs		A0A0G2JNB4 Q04118	Q96HL8
PDB IDs		Not available	2D8H
GO Terms Enriched among Interactors		Regulation Of Mitochondrial Membrane Potential Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Posterior Compartment Specification Anterior Compartment Pattern Formation Mitochondrial MRNA Processing Regulation Of Proton-transporting ATPase Activity, Rotational Mechanism TRC Complex	Bergmann Glial Cell Differentiation Astrocyte Development Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Prostate Induction Gene Expression Cellular Response To Steroid Hormone Stimulus Nuclear Receptor-mediated Signaling Pathway Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Schwann Cell Proliferation Astrocyte Differentiation Kinase Binding Intermediate Filament Organization Schwann Cell Proliferation Glial Cell Development Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Synaptic Vesicle Uncoating Positive Regulation Of Endosome Organization Grb2-Sos Complex Negative Regulation Of NK T Cell Activation Negative Regulation Of NK T Cell Proliferation Positive Regulation Of SREBP Signaling Pathway Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Positive Regulation Of Viral Budding Via Host ESCRT Complex Male Genitalia Morphogenesis POU Domain Binding Glial Cell Differentiation Phosphatidylinositol Phosphate 4-phosphatase Activity SH3 Domain Binding NK T Cell Differentiation Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Cellular Response To Lipid Negative Regulation Of Neuron Projection Development