STYK1 and ATG14

Number of citations of the paper that reports this interaction (PubMedID 31696776)
62

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		STYK1	ATG14
Description		serine/threonine/tyrosine kinase 1	autophagy related 14
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Phagophore Assembly Site Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Axoneme Membrane Cytoplasmic Vesicle Protein-containing Complex Phagophore Assembly Site Membrane Phosphatidylinositol 3-kinase Complex, Class III Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Phagocytic Vesicle Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Phagophore Assembly Site Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Protein Binding Phosphatidylinositol 3-kinase Regulator Activity Protein-membrane Adaptor Activity GTPase Binding Phosphatidylinositol 3-kinase Inhibitor Activity
	Biological Process		Autophagosome Assembly Mitophagy Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Targeting To Lysosome Autophagy Endosome To Lysosome Transport Cellular Response To Starvation Post-transcriptional Regulation Of Gene Expression Macroautophagy Autophagosome Membrane Docking Regulation Of Macroautophagy Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Early Endosome To Late Endosome Transport Innate Immune Response Defense Response To Virus Regulation Of Protein Complex Stability Regulation Of Triglyceride Metabolic Process Autophagosome Maturation Response To Mitochondrial Depolarisation
Pathways			Macroautophagy SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS			Eosinophil percentage of white cells ( 32888494) Platelet distribution width ( 27863252) Statin-induced myopathy ( 31220337) Testicular germ cell tumor ( 28604728) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: ATG14 BECN1 DUXAP9 ERBB2 PIK3C3	14 interacting genes: ATG13 EXOC1 FSD2 MARCHF7 MIS18A OTUD3 OTUD7B RACK1 SNAPIN STAMBP STYK1 ULK2 USP2 YOD1
Entrez ID		55359	22863
HPRD ID		15447	13820
Ensembl ID		ENSG00000060140	ENSG00000126775
Uniprot IDs		Q6J9G0	Q6ZNE5
PDB IDs			6HOL 8SOR 9C82 9MHF 9MHG 9MHH
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol 3-kinase Complex, Class III Phosphatidylinositol-3-phosphate Biosynthetic Process Early Endosome To Late Endosome Transport Phagophore Assembly Site Protein Targeting To Lysosome Cellular Response To Glucose Starvation Phosphatidylinositol Phosphate Biosynthetic Process Autophagosome Maturation Protein Targeting To Vacuole Protein Localization To Lysosome Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I Establishment Of Protein Localization To Vacuole Autophagosome Response To Mitochondrial Depolarisation Phagocytic Vesicle Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Localization To Vacuole Autophagosome Assembly Autophagosome Organization Phosphatidylinositol Biosynthetic Process Lysosomal Transport Phosphatidylinositol Metabolic Process Protein-containing Complex Disassembly Macroautophagy Vacuolar Transport Protein Localization To Organelle Glycerophospholipid Biosynthetic Process Vacuole Organization Cellular Response To Starvation Regulation Of Macroautophagy Protein Targeting Phospholipid Biosynthetic Process Response To Starvation Cytoplasmic Vesicle Intracellular Signaling Cassette Glycerophospholipid Metabolic Process Cellular Response To Nutrient Levels Endosomal Transport Autophagy GTPase Binding Glycerolipid Metabolic Process Phospholipid Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus Establishment Of Protein Localization To Organelle Response To Epidermal Growth Factor Regulation Of Autophagy Positive Regulation Of Protein Modification Process Mitophagy Phosphate-containing Compound Metabolic Process	Protein Deubiquitination Protein Modification By Small Protein Removal Protein K11-linked Deubiquitination Cysteine-type Deubiquitinase Activity Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Post-translational Protein Modification Cysteine-type Peptidase Activity Protein K27-linked Deubiquitination Protein Modification Process Peptidase Activity Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Piecemeal Microautophagy Of The Nucleus K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Protein Metabolic Process Phagophore Assembly Site Membrane Microautophagy Nucleophagy Perinuclear Region Of Cytoplasm Deubiquitinase Activity Negative Regulation Of Intracellular Signal Transduction Macroautophagy Phagophore Assembly Site Cyclin Binding Vacuole Organization Negative Regulation Of Cell Projection Organization Cytosol Rescue Of Stalled Ribosome Ribosome Disassembly Cytoplasm Somatic Sensory System Development Positive Regulation Of Late Endosome To Lysosome Transport Protein Stabilization Mitophagy Translational Elongation Mitotic Cytokinesis Autophagy Autophagy Of Mitochondrion IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Negative Regulation Of Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Organelle Disassembly Autophagosome Negative Regulation Of Cellular Component Organization Hippocampal Neuron Apoptotic Process Protein K6-linked Deubiquitination Pericentric Heterochromatin Organization
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