LARP6 and MIR145

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		LARP6	MIR145
Description		La ribonucleoprotein 6, translational regulator	microRNA 145
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Ribonucleoprotein Complex	RISC Complex Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Myosin Binding RNA Stem-loop Binding MRNA 5'-UTR Binding Sequence-specific MRNA Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	RNA Processing Regulation Of Translation Positive Regulation Of Collagen Biosynthetic Process	Regulation Of Smooth Muscle Contraction Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Ectodermal Cell Differentiation Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Fibroblast Migration Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-10 Production Regulation Of Collagen Biosynthetic Process MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Vascular Associated Smooth Muscle Cell Differentiation Myofibroblast Differentiation Angiotensin-activated Signaling Pathway Positive Regulation Of Macrophage Activation Establishment Or Maintenance Of Cell Type Involved In Phenotypic Switching Positive Regulation Of Macrophage Differentiation Mesodermal Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Aorta Smooth Muscle Tissue Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cholesterol Efflux Positive Regulation Of Cellular Response To Hypoxia Regulation Of Phenotypic Switching Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Somatic Stem Cell Population Maintenance Negative Regulation Of Somatic Stem Cell Division Negative Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Insulin-related traits (multivariate analysis) ( 32002517) Proinsulin levels ( 21873549)
Interacting Genes		5 interacting genes: ADARB1 APP CRYAA MIR141 MIR145	80 interacting genes: ADARB1 AGO2 APOBEC3B AQR C1QBP DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 FAM98A FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP6 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NONO NUDT16L1 NUDT21 PDCD11 PGAM5 PRMT1 PTBP1 PTBP3 PUF60 PUM1 RARS1 RBM14 RBM4 RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SYNCRIP TAF15 TENT2 TIAL1 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX3 ZFR ZNF346
Entrez ID		55323	406937
HPRD ID		10966
Ensembl ID		ENSG00000166173	ENSG00000276365
Uniprot IDs		Q9BRS8
PDB IDs		2MTF 2MTG
Enriched GO Terms of Interacting Partners?		Hypoglossal Nerve Morphogenesis Negative Regulation Of Metabolic Process Muscle Tissue Morphogenesis Negative Regulation Of Macromolecule Metabolic Process Anatomical Structure Morphogenesis Regulation Of Protein Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Translation Negative Regulation Of Gene Expression Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Inflammatory Response MiRNA-mediated Gene Silencing By Inhibition Of Translation RISC Complex MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Somatic Stem Cell Division Negative Regulation Of Interleukin-16 Production Negative Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Axonogenesis Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Negative Regulation Of Protein Metabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization MRNA 3'-UTR Binding Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Transformation Of Host Cell By Virus Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Establishment Or Maintenance Of Cell Type Involved In Phenotypic Switching Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing MRNA Processing Nucleic Acid Metabolic Process MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Spliceosomal Complex Regulation Of RNA Splicing Nucleus Catalytic Step 2 Spliceosome Ribonucleoprotein Complex Nucleoplasm Macromolecule Metabolic Process MiRNA Binding Regulation Of Translation Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of Gene Expression RNA Stabilization Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of MRNA Catabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of MRNA Stability MRNA 5'-UTR Binding Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Metabolic Process U2 SnRNP Double-stranded RNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Translation
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