BTN1A1 and XDH

Number of citations: 46 (PubMedID 12456835)
Data Source: HPRD (in vivo)

		BTN1A1	XDH
Name		butyrophilin subfamily 1 member A1	xanthine dehydrogenase
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Region Extracellular Space Cytoplasm Peroxisome Cytosol Sarcoplasmic Reticulum
	Molecular Function	Signaling Receptor Binding Protein Binding Signaling Receptor Activity	Xanthine Dehydrogenase Activity Xanthine Oxidase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Protein Homodimerization Activity Molybdopterin Cofactor Binding Metal Ion Binding Flavin Adenine Dinucleotide Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding Hypoxanthine Dehydrogenase Activity Hypoxanthine Oxidase Activity FAD Binding
	Biological Process	Regulation Of Cytokine Production T Cell Receptor Signaling Pathway	Allantoin Metabolic Process Guanine Catabolic Process Inosine Catabolic Process Deoxyinosine Catabolic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process Deoxyguanosine Catabolic Process AMP Catabolic Process IMP Catabolic Process Lactation Hypoxanthine Catabolic Process Xanthine Catabolic Process Iron-sulfur Cluster Assembly Regulation Of Epithelial Cell Differentiation Amide Catabolic Process GMP Catabolic Process DGMP Catabolic Process DAMP Catabolic Process
Pathways		Butyrophilin (BTN) family interactions	Purine catabolism Butyrophilin (BTN) family interactions Azathioprine ADME
Drugs		None	Allopurinol Levocarnitine Topiroxostat Flavin adenine dinucleotide Dioxo(sulfanyl)molybdenum Eniluracil Niraxostat Febuxostat Oxypurinol
Diseases		None	Xanthinuria
GWAS		Age at first sexual intercourse ( 27089180 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Body mass index ( 28552196 ) Brain morphology (MOSTest) ( 32665545 ) Educational attainment (years of education) ( 23722424 ) Fish- and plant-related diet ( 32066663 ) Gastroesophageal reflux disease ( 31527586 34187846 ) Hip circumference adjusted for BMI ( 34021172 ) Intelligence (MTAG) ( 29326435 ) Iron status biomarkers ( 19084217 ) Liver iron content ( 34128465 ) Refractive error ( 32231278 ) Subcortical volume (MOSTest) ( 32665545 ) Weight ( 28552196 )	Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600 ) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) Male-pattern baldness ( 28196072 ) Multiple system atrophy ( 27629089 ) Obesity-related traits ( 23251661 ) Parahippocampal gyrus volume ( 31530798 ) Periventricular white matter hyperintensities ( 32517579 ) Zinc levels ( 26025379 )
Interacting Genes		4 interacting genes: MEOX2 MOSPD2 NEIL3 XDH	2 interacting genes: BTN1A1 GRIP1
Entrez ID		696	7498
HPRD ID		03365	06363
Ensembl ID		ENSG00000124557	ENSG00000158125
Uniprot IDs		Q13410 Q4VAN2	P47989
PDB IDs		Not available	2CKJ 2E1Q
GO Terms Enriched among Interactors		Xanthine Catabolic Process Xanthine Dehydrogenase Activity Xanthine Oxidase Activity Hypoxanthine Oxidase Activity Hypoxanthine Catabolic Process Hypoxanthine Dehydrogenase Activity MCM Complex Binding Guanine Catabolic Process Deoxyguanosine Catabolic Process Inosine Catabolic Process Deoxyinosine Catabolic Process Somite Specification Molybdopterin Cofactor Binding Hypoxanthine Metabolic Process Purine Ribonucleoside Catabolic Process DAMP Catabolic Process GMP Catabolic Process AMP Catabolic Process Purine Deoxyribonucleoside Metabolic Process Deoxyadenosine Catabolic Process Adenosine Catabolic Process Purine Nucleobase Catabolic Process IMP Catabolic Process Depurination Endoplasmic Reticulum-endosome Membrane Contact Site FFAT Motif Binding Guanine Metabolic Process Deoxyribonucleoside Catabolic Process DGMP Catabolic Process DGMP Metabolic Process Purine Nucleoside Catabolic Process Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Allantoin Metabolic Process Bubble DNA Binding Adenosine Metabolic Process DNA N-glycosylase Activity Purine Nucleoside Monophosphate Catabolic Process Single Strand Break Repair DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Organelle Membrane Contact Site Amide Catabolic Process Nucleobase-containing Small Molecule Catabolic Process Deoxyribonucleoside Monophosphate Catabolic Process Segment Specification Somite Development Base-excision Repair, AP Site Formation Lipid Droplet Formation IMP Metabolic Process Purine Nucleobase Metabolic Process	Endosome To Plasma Membrane Protein Transport Establishment Of Protein Localization To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Regulation Of Neuron Projection Arborization Neurotransmitter Receptor Transport Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Protein Localization To Postsynapse Signaling Receptor Complex Adaptor Activity Protein Localization To Postsynaptic Membrane Receptor Localization To Synapse Establishment Of Protein Localization To Plasma Membrane Protein Localization To Synapse Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels