FAIM and DAPP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAIM	DAPP1
Description		Fas apoptotic inhibitory molecule	dual adaptor of phosphotyrosine and 3-phosphoinositides 1
Image
GO Annotations	Cellular Component	Cytoplasm	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Phospholipid Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Apoptotic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Protein Dephosphorylation Signal Transduction
Pathways			Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		Blood protein levels ( 30072576) Male-pattern baldness ( 28196072)	Red cell distribution width ( 32888494) Stroke ( 32693751)
Interacting Genes		10 interacting genes: CDR2L DAPP1 INCA1 LHX3 LMNA RSPH1 SPRY2 TRIM62 ZNF16 ZRANB1	23 interacting genes: BTK CNDP2 ERBB3 FAIM FCHSD2 FXN GSTCD HSD3B7 HSPA1A LCK LYN MAP4K1 MGARP MYLIP PLAGL2 PLCG1 PLCG2 RBP7 RPL23 SRC TM4SF19 TNFAIP1 ZNHIT1
Entrez ID		55179	27071
HPRD ID		16874	05773
Ensembl ID		ENSG00000158234	ENSG00000070190
Uniprot IDs		Q9NVQ4	J3KNB3 Q9UN19
PDB IDs		2KW1 3MX7	1FAO 1FB8
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Organelle Localization Regulation Of Apoptotic Process Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity DNA Double-strand Break Attachment To Nuclear Envelope Cytoskeleton Organization Microtubule Cytoskeleton Organization Negative Regulation Of Programmed Cell Death Establishment Of Organelle Localization Negative Regulation Of Apoptotic Process Structural Constituent Of Nuclear Lamina Microtubule-based Process Cellular Response To Sodium Dodecyl Sulfate Regulation Of Phosphorylation Medial Motor Column Neuron Differentiation Ventral Spinal Cord Interneuron Specification Lung Development Prolactin Secreting Cell Differentiation Somatotropin Secreting Cell Differentiation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Lung Growth Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Lens Fiber Cell Differentiation Golgi To Secretory Granule Transport Protein K29-linked Deubiquitination Positive Regulation Of Antifungal Innate Immune Response Radial Spoke Head 1 Radial Spoke Head 3 Lamin Filament Nuclear Pore Localization Ubiquitin-protein Transferase Inhibitor Activity Protein K33-linked Deubiquitination Radial Spoke Head	Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Phospholipase Activator Activity Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Programmed Cell Death Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phospholipase Binding Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Response To Lipid Immune Response-activating Signaling Pathway Membrane Raft Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Fc-gamma Receptor Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Histamine Secretion By Mast Cell Positive Regulation Of Immune Response Protein Autophosphorylation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of MAPK Cascade Cellular Response To Lipid Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Developmental Process T Cell Costimulation Positive Regulation Of Immune System Process Histamine Secretion Positive Regulation Of Epithelial Cell Migration Protein Kinase Activity Positive Regulation Of Innate Immune Response Signaling Receptor Activator Activity Release Of Sequestered Calcium Ion Into Cytosol Histamine Transport Negative Regulation Of Sequestering Of Calcium Ion
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