ZFPL1 and CYBRD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZFPL1	CYBRD1
Description		zinc finger protein like 1	cytochrome b reductase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Golgi Apparatus Membrane	Lysosomal Membrane Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions Identical Protein Binding Metal Ion Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity
	Biological Process	Regulation Of DNA-templated Transcription Vesicle-mediated Transport	Intracellular Iron Ion Homeostasis Response To Iron Ion Reductive Iron Assimilation Transmembrane Transport Multicellular Organismal-level Iron Ion Homeostasis Ascorbate Homeostasis
Pathways			Iron uptake and transport
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Asthma (childhood onset) ( 34022066) Body fat distribution (arm fat ratio) ( 30664634) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Pulse pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		64 interacting genes: AHNAK2 AQP6 ATP5MF BIK BSND CD3E CGRRF1 CLEC10A CLEC7A CPLX4 CREB3L1 CYBRD1 EBP ELOVL4 ERGIC3 FAM209A FATE1 FKBP7 FKBP8 FNDC9 FRMD3 GORAB GPR42 HIBADH KASH5 KLRC1 LDLRAD1 LEUTX LIME1 LINC00839 MFF MGST3 MIP MRM3 MRPS18B MS4A3 MTERF3 PGRMC2 PLEKHO1 PVR RELL2 SCN3B SGMS2 SHISAL1 SLC10A6 SLC19A3 SLC71A2 SLC7A14 SMIM3 SSMEM1 STX1A STX2 STX4 SYAP1 SYT1 TEX29 TM4SF19 TMEM106C TMEM139 TMEM14B TMEM237 TMEM31 TMPRSS2 TSTD2	20 interacting genes: CREB3 FKBP8 GIMAP5 GOSR2 HMOX1 LMNA LPAR3 NEDD4L PLP2 RABAC1 SEC22A SERP1 SERP2 STX4 STX7 TMEM120A TMEM65 VAPA VAPB ZFPL1
Entrez ID		7542	79901
HPRD ID		15729	05764
Ensembl ID		ENSG00000162300	ENSG00000071967
Uniprot IDs		O95159	Q53TN4
PDB IDs			5ZLE 5ZLG
Enriched GO Terms of Interacting Partners?		Membrane SNARE Binding Protein Binding SNARE Complex Endomembrane System Vesicle Docking Cornified Envelope Assembly Organelle Localization By Membrane Tethering Synaptic Vesicle Exocytosis Membrane Docking SNAP Receptor Activity	Endoplasmic Reticulum Membrane SNAP Receptor Activity Endoplasmic Reticulum Membrane Organization Membrane Fusion Endoplasmic Reticulum Unfolded Protein Response Organelle Localization By Membrane Tethering Membrane Docking Response To Unfolded Protein FFAT Motif Binding Membrane COPII-coated Vesicle Budding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum-plasma Membrane Tethering SNARE Complex Vesicle Organization Vesicle-mediated Transport Endoplasmic Reticulum Localization SNARE Binding Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral Genome Replication Host-mediated Suppression Of Viral Genome Replication Response To Endoplasmic Reticulum Stress Organelle Localization Vesicle Fusion Organelle Membrane Fusion Endomembrane System Intracellular Transport Golgi Vesicle Transport Organelle Fusion Viral Release From Host Cell Intracellular Protein Localization Endoplasmic Reticulum Exit Site Viral Process Vesicle Budding From Membrane Protein-membrane Adaptor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Host-mediated Activation Of Viral Process Positive Regulation Of Developmental Growth Regulation Of Protein Localization To Cell Surface Regulation Of Apoptotic Signaling Pathway Perinuclear Region Of Cytoplasm Cellular Localization Protein Transport Sphingomyelin Phosphodiesterase Activator Activity Positive Regulation Of Deacetylase Activity Establishment Of Localization In Cell Cellular Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Heme Oxidation
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