SEC61A2 and TOMM6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SEC61A2	TOMM6
Description		SEC61 translocon subunit alpha 2	translocase of outer mitochondrial membrane 6
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Membrane	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane TOM Complex
	Molecular Function	Signal Sequence Binding Protein Binding Protein Transmembrane Transporter Activity Ribosome Binding	Protein Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Protein Transport Post-translational Protein Targeting To Membrane, Translocation	Protein Transport Protein Insertion Into Mitochondrial Outer Membrane
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane	Mitochondrial protein import PINK1-PRKN Mediated Mitophagy
Drugs
Diseases
GWAS			Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: APOB TOMM6	14 interacting genes: AQP6 C1orf159 CD68 CERS4 ERGIC3 FFAR3 GLP1R HUNK ODF4 SEC61A2 SLC10A1 SLC16A2 SLC18A2 TMEM14B
Entrez ID		55176	100188893
HPRD ID		15317	19464
Ensembl ID		ENSG00000065665	ENSG00000214736
Uniprot IDs		B3KQ68 Q8TC24 Q9H9S3	Q96B49
PDB IDs			7CK6 7CP9 7VBY 7VC4 7VD2 7VDD 8XVA 9EIH 9EII 9EIJ
Enriched GO Terms of Interacting Partners?		Lipoprotein Transport Positive Regulation Of Macrophage Derived Foam Cell Differentiation Protein-lipid Complex Assembly Low-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Mature Chylomicron Endosome Lumen Triglyceride Mobilization Triglyceride Catabolic Process Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Receptor Binding Acylglycerol Catabolic Process Chylomicron Positive Regulation Of Cholesterol Storage Protein Transport Endocytic Vesicle Lumen Very-low-density Lipoprotein Particle Assembly Lipoprotein Biosynthetic Process Lipid Transporter Activity Cholesterol Efflux Cholesterol Transfer Activity Low-density Lipoprotein Particle Regulation Of Cholesterol Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Smooth Endoplasmic Reticulum Lipoprotein Catabolic Process Chylomicron Remnant Positive Regulation Of Lipid Storage Low-density Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Plasma Lipoprotein Particle Clearance Plasma Lipoprotein Particle Assembly Lipase Binding Endoplasmic Reticulum Exit Site Mitochondrial Outer Membrane Translocase Complex TOM Complex Protein Insertion Into Mitochondrial Outer Membrane Establishment Of Protein Localization To Mitochondrial Membrane Protein Insertion Into Mitochondrial Membrane Plasma Lipoprotein Particle Remodeling Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Regulation Of Lipid Storage Establishment Of Protein Localization Regulation Of Cholesterol Metabolic Process Cellular Response To Amyloid-beta Triglyceride Metabolic Process Response To Amyloid-beta Artery Morphogenesis Cholesterol Transport	Post-translational Protein Targeting To Membrane, Translocation Hormone Secretion Hormone Transport Transmembrane Transport Membrane Intracellular Protein Transmembrane Transport Signal Release Nitrate Transmembrane Transporter Activity Glucagon-like Peptide 1 Receptor Activity Negative Regulation Of Blood Pressure Serotonin Secretion By Mast Cell Somato-dendritic Dopamine Secretion Regulation Of Hormone Levels PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Thyroid-stimulating Hormone Secretion Aminergic Neurotransmitter Loading Into Synaptic Vesicle Retrograde Transporter Complex, Golgi To ER Protein Transmembrane Transport Glucagon Receptor Activity Histamine Uptake Serotonin:sodium:chloride Symporter Activity
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