TOMM6 and SEC61A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TOMM6	SEC61A2
Description		translocase of outer mitochondrial membrane 6	SEC61 translocon subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane TOM Complex	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Signal Sequence Binding Protein Binding Protein Transmembrane Transporter Activity Ribosome Binding
	Biological Process	Protein Transport Protein Insertion Into Mitochondrial Outer Membrane	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Protein Transport Post-translational Protein Targeting To Membrane, Translocation
Pathways		Mitochondrial protein import PINK1-PRKN Mediated Mitophagy	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		14 interacting genes: AQP6 C1orf159 CD68 CERS4 ERGIC3 FFAR3 GLP1R HUNK ODF4 SEC61A2 SLC10A1 SLC16A2 SLC18A2 TMEM14B	2 interacting genes: APOB TOMM6
Entrez ID		100188893	55176
HPRD ID		19464	15317
Ensembl ID		ENSG00000214736	ENSG00000065665
Uniprot IDs		Q96B49	B3KQ68 Q8TC24 Q9H9S3
PDB IDs		7CK6 7CP9 7VBY 7VC4 7VD2 7VDD 8XVA 9EIH 9EII 9EIJ
Enriched GO Terms of Interacting Partners?		Post-translational Protein Targeting To Membrane, Translocation Hormone Secretion Hormone Transport Transmembrane Transport Membrane Intracellular Protein Transmembrane Transport Signal Release Nitrate Transmembrane Transporter Activity Glucagon-like Peptide 1 Receptor Activity Negative Regulation Of Blood Pressure Serotonin Secretion By Mast Cell Somato-dendritic Dopamine Secretion Regulation Of Hormone Levels PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Thyroid-stimulating Hormone Secretion Aminergic Neurotransmitter Loading Into Synaptic Vesicle Retrograde Transporter Complex, Golgi To ER Protein Transmembrane Transport Glucagon Receptor Activity Histamine Uptake Serotonin:sodium:chloride Symporter Activity	Lipoprotein Transport Positive Regulation Of Macrophage Derived Foam Cell Differentiation Protein-lipid Complex Assembly Low-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Mature Chylomicron Endosome Lumen Triglyceride Mobilization Triglyceride Catabolic Process Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Receptor Binding Acylglycerol Catabolic Process Chylomicron Positive Regulation Of Cholesterol Storage Protein Transport Endocytic Vesicle Lumen Very-low-density Lipoprotein Particle Assembly Lipoprotein Biosynthetic Process Lipid Transporter Activity Cholesterol Efflux Cholesterol Transfer Activity Low-density Lipoprotein Particle Regulation Of Cholesterol Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Smooth Endoplasmic Reticulum Lipoprotein Catabolic Process Chylomicron Remnant Positive Regulation Of Lipid Storage Low-density Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Plasma Lipoprotein Particle Clearance Plasma Lipoprotein Particle Assembly Lipase Binding Endoplasmic Reticulum Exit Site Mitochondrial Outer Membrane Translocase Complex TOM Complex Protein Insertion Into Mitochondrial Outer Membrane Establishment Of Protein Localization To Mitochondrial Membrane Protein Insertion Into Mitochondrial Membrane Plasma Lipoprotein Particle Remodeling Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Regulation Of Lipid Storage Establishment Of Protein Localization Regulation Of Cholesterol Metabolic Process Cellular Response To Amyloid-beta Triglyceride Metabolic Process Response To Amyloid-beta Artery Morphogenesis Cholesterol Transport
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