ARHGEF10L and SCN2A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		ARHGEF10L	SCN2A
Gene Name		Rho guanine nucleotide exchange factor (GEF) 10-like	sodium channel, voltage gated, type II alpha subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity	Voltage-gated Sodium Channel Activity
	Biological Process	Positive Regulation Of Rho GTPase Activity	Sodium Ion Transport Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Membrane Depolarization During Action Potential
Pathways			Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS		Basal cell carcinoma ( 18849993) Obesity-related traits ( 23251661) Response to hepatitis C treatment ( 22095909)
Protein-Protein Interactions		4 interactors: ANXA9 DRAP1 NR4A1 SCN2A	5 interactors: ANK3 ARHGEF10L MPP3 RNF130 SCN4B
Entrez ID		55160	6326
HPRD ID		07679	03133
Ensembl ID		ENSG00000074964	ENSG00000136531
Uniprot IDs		Q5VXI4 Q9HCE6	Q99250
PDB IDs			2KAV
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress	Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Regulation Of Sodium Ion Transport Action Potential Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Ion Transport Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cellular Response To Magnesium Ion Regulation Of Membrane Depolarization During Action Potential AV Node Cell To Bundle Of His Cell Communication Regulation Of Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Action Potential Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Cell Communication By Electrical Coupling Cytoskeletal Anchoring At Plasma Membrane Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization SREBP Signaling Pathway Regulation Of Actin Filament-based Process Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Response To Sterol Depletion Positive Regulation Of Sodium Ion Transmembrane Transport Magnesium Ion Homeostasis Response To Magnesium Ion Negative Regulation Of Cation Channel Activity Negative Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Membrane Assembly Regulation Of Heart Rate By Cardiac Conduction Golgi To Plasma Membrane Protein Transport Membrane Biogenesis Neuronal Action Potential Regulation Of Potassium Ion Transmembrane Transporter Activity Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Protein Targeting To Membrane Regulation Of Ion Transport Golgi To Plasma Membrane Transport Membrane Depolarization During Action Potential Regulation Of Membrane Depolarization Cardiac Muscle Cell Action Potential
Tagcloud ?			16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications spasms stxbp1 xq28
Tagcloud (Difference) ?			16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications spasms stxbp1 xq28
Tagcloud (Intersection) ?