HAUS2 and XRCC4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HAUS2	XRCC4
Description		HAUS augmin like complex subunit 2	X-ray repair cross complementing 4
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule HAUS Complex Mitotic Spindle Microtubule	Condensed Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex
	Molecular Function	Protein Binding	DNA Binding Protein Binding Ligase Activity Enzyme Binding Identical Protein Binding FHA Domain Binding
	Biological Process	Microtubule Nucleation Centrosome Cycle Regulation Of Microtubule Nucleation Microtubule Organizing Center Organization Spindle Assembly Cell Division	DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Response To X-ray Immunoglobulin V(D)J Recombination Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Protein Localization To Site Of Double-strand Break
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)
Drugs			S-(Dimethylarsenic)Cysteine
Diseases
GWAS		Bipolar disorder ( 31043756) Glucose homeostasis traits ( 25524916)	Clozapine-induced agranulocytosis ( 25187353) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Osteoarthritis biomarkers ( 25057126) Squamous cell lung carcinoma ( 28604730) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)
Interacting Genes		3 interacting genes: FXYD6 MAPK6 XRCC4	23 interacting genes: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 GSC2 GZMB HAUS2 IFFO1 KRT27 LIG4 MAGEA6 NBN NHEJ1 OGT PNKP PRKDC VIM
Entrez ID		55142	7518
HPRD ID		07675	15951
Ensembl ID		ENSG00000137814	ENSG00000152422
Uniprot IDs		H3BP16 Q9NVX0	Q13426 Q7Z763
PDB IDs		7SQK	1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03 4XA4 5CHX 5CJ0 5CJ4 5E50 5WJ7 5WLZ 6ABO 7LSY 7LT3 7M3P 7NFC 7NFE 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB
Enriched GO Terms of Interacting Partners?		Septin Cytoskeleton FHA Domain Binding Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Phospholipid Translocation DNA-dependent Protein Kinase-DNA Ligase 4 Complex Positive Regulation Of Ligase Activity Immunoglobulin V(D)J Recombination DNA Ligase IV Complex Nonhomologous End Joining Complex Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity MAP Kinase Activity Response To Lithium Ion Regulation Of Plasma Membrane Organization Cellular Response To Lithium Ion Positive Regulation Of Phospholipid Transport Positive Regulation Of Sodium Ion Transmembrane Transport V(D)J Recombination Response To X-ray Protein Localization To Site Of Double-strand Break Positive Regulation Of Dendritic Spine Development Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Base-excision Repair Positive Regulation Of Transport Regulation Of Sodium Ion Transmembrane Transport Sodium Channel Regulator Activity Positive Regulation Of Sodium Ion Transport Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Regulation Of Membrane Lipid Distribution Regulation Of Dendritic Spine Development Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Sodium Ion Transport	Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair DNA Repair DNA Metabolic Process DNA Damage Response DNA-dependent Protein Kinase-DNA Ligase 4 Complex Somatic Recombination Of Immunoglobulin Gene Segments Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Site Of Double-strand Break Protein Localization To Chromosome Somatic Cell DNA Recombination Single Strand Break Repair Somatic Diversification Of Immunoglobulins DNA Recombination Polynucleotide 3'-phosphatase Activity V(D)J Recombination DNA Ligase IV Complex Protein Localization To Site Of Double-strand Break Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Cellular Response To Stress Organelle Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Double-strand Break Repair Double-strand Break Repair Via Alternative Nonhomologous End Joining Nucleus Double-strand Break Repair Via Classical Nonhomologous End Joining Damaged DNA Binding Lymphoid Progenitor Cell Differentiation B Cell Activation Double-stranded RNA Binding Nucleic Acid Metabolic Process Protein Localization To Organelle Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA Repair Response To Stress Positive Regulation Of Double-strand Break Repair DNA Damage Checkpoint Signaling Telomere Maintenance Positive Regulation Of Chromosome Organization Sin3-type Complex PML Body Regulation Of DNA Metabolic Process DNA Endonuclease Activity Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response DNA Repair-dependent Chromatin Remodeling
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