LARP1B and POLR2J

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		LARP1B	POLR2J
Gene Name		La ribonucleoprotein domain family, member 1B	polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex
	Molecular Function	Poly(A) RNA Binding	RNA Polymerase II Activity DNA Binding DNA-directed RNA Polymerase Activity Protein Binding LRR Domain Binding Protein Dimerization Activity
	Biological Process		MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Viral Transcription
Pathways			RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP KIF2A POLR2J TRIM69 UBC	8 interactors: AATF BAG6 CD14 LARP1B POLR1C POLR2C POLR2K SATB1
Entrez ID		55132	5439
HPRD ID		10963	16038
Ensembl ID		ENSG00000138709	ENSG00000005075
Uniprot IDs		G3V0E9 G3XAJ5 Q659C4	P52435
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Notch Signaling Pathway Synaptic Growth At Neuromuscular Junction Transcription Initiation From RNA Polymerase II Promoter Collateral Sprouting In Absence Of Injury Apoptotic Process Intracellular Receptor Signaling Pathway Programmed Cell Death Cell Death Death Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process DNA-templated Transcription, Initiation Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Cycle Phase Transition Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Positive Regulation Of Cell Cycle Antigen Processing And Presentation Positive Regulation Of Proteolysis Microtubule-based Movement Neuron Remodeling Response To Stress Microtubule Depolymerization Viral Protein Processing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Mitotic Cell Cycle Blood Coagulation MRNA Processing Hemostasis Cellular Copper Ion Homeostasis Regulation Of Cell Cycle Process Mitotic Spindle Assembly Notch Receptor Processing Copper Ion Homeostasis Suckling Behavior MRNA Metabolic Process Virion Assembly Viral Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway RNA Processing Protein Ubiquitination	DNA-templated Transcription, Elongation Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter DNA-templated Transcription, Initiation 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter PiRNA Metabolic Process 7-methylguanosine RNA Capping Cellular Response To DNA Damage Stimulus Response To Stress Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Transcription From RNA Polymerase III Promoter Apoptotic Process Programmed Cell Death Immune System Process Positive Regulation Of Cytokine Production Cell Death Death Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Type I Interferon Production Nucleotide-excision Repair Regulation Of Cytokine Production Viral Process Regulation Of Type I Interferon Production Regulation Of Gene Expression Cellular Response To Stress Response To Stimulus Stem Cell Maintenance Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Innate Immune Response Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Superoxide Anion Generation Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Tail-anchored Membrane Protein Insertion Into ER Membrane MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Stem Cell Development Transcription, DNA-templated Protein Insertion Into ER Membrane
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