ZWILCH and KNTC1

Number of citations: 45 (PubMedID 12686595)
Data Source: HPRD (in vitro, in vivo)

		ZWILCH	KNTC1
Name		zwilch kinetochore protein	kinetochore associated 1
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Kinetochore Microtubule Cytosol RZZ Complex	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Chromosome Cytoplasm Spindle Kinetochore Microtubule Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton RZZ Complex
	Molecular Function	Protein Binding	Protein Binding Small GTPase Binding
	Biological Process	Mitotic Spindle Assembly Checkpoint Signaling Protein Localization To Kinetochore Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore	Mitotic Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Exit From Mitosis Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein-containing Complex Assembly Protein Localization To Kinetochore Involved In Kinetochore Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS		Body mass index ( 29273807 )	A body shape index ( 34021172 ) Adult body size ( 32376654 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body mass index ( 28892062 ) Hand grip strength ( 29691431 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Menopause (age at onset) ( 26414677 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Walking pace ( 33128006 )
Novel Interactors		None recorded	1 novel interactors: MPHOSPH9
Interacting Genes		3 interacting genes: KNTC1 UBC ZW10	3 interacting genes: CEBPA PIAS4 ZWILCH
Entrez ID		55055	9735
HPRD ID		07640	09561
Ensembl ID		ENSG00000174442	ENSG00000184445
Uniprot IDs		A8K4T3 Q9H900	P50748
PDB IDs		3IF8 7QPG	7QPG
GO Terms Enriched among Interactors		RZZ Complex Protein Localization To Kinetochore Regulation Of Exit From Mitosis Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Checkpoint Signaling Mitotic Sister Chromatid Segregation Negative Regulation Of Mitotic Metaphase/anaphase Transition Kinetochore Microtubule Negative Regulation Of Mitotic Nuclear Division Protein Localization To Chromosome, Centromeric Region Sister Chromatid Segregation Nuclear Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Protein Localization To Chromosome Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Protein Localization To Kinetochore Involved In Kinetochore Assembly Chromosome Segregation Regulation Of Nuclear Division Spindle Pole Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Kinetochore Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Dsl1/NZR Complex Spindle Regulation Of Chromosome Organization Negative Regulation Of Cell Cycle Process Centromeric DNA Binding Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Division Protein Tag Activity Regulation Of Mitotic Cell Cycle Protein Localization To Organelle Chromosome Negative Regulation Of Cellular Component Organization Regulation Of Cell Cycle Process Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Mitotic Metaphase Chromosome Alignment Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum	Nuclear Matrix RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Limb Epidermis Development CHOP-C/EBP Complex Steroid Metabolic Process White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Keratinocyte Apoptotic Process RZZ Complex Urea Metabolic Process HMG Box Domain Binding Response To Phenylpropanoid Negative Regulation Of Cell Cycle Urea Cycle STAT Family Protein Binding Fat Cell Proliferation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Protein Localization To Chromatin Regulation Of Keratinocyte Apoptotic Process Vitamin D Metabolic Process SUMO Ligase Activity Negative Regulation Of Protein Localization To Chromatin Transferase Complex Positive Regulation Of Protein Sumoylation Protein Localization To Kinetochore Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Osteoblast Development