KNTC1

Description		kinetochore associated 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Chromosome Cytoplasm Spindle Kinetochore Microtubule Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton RZZ Complex
	Molecular Function	Protein Binding Small GTPase Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Exit From Mitosis Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein-containing Complex Assembly Protein Localization To Kinetochore Involved In Kinetochore Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Hand grip strength ( 29691431) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin concentration ( 32888494) Menopause (age at onset) ( 26414677) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006)
Novel Interacting Genes		1 novel interacting genes: MPHOSPH9
Interacting Genes		3 interacting genes: CEBPA PIAS4 ZWILCH
Entrez ID		9735
HPRD ID		09561
Ensembl ID		ENSG00000184445
Uniprot IDs		P50748
PDB IDs		7QPG
Enriched GO Terms of Interacting Partners?		Nuclear Matrix RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Limb Epidermis Development CHOP-C/EBP Complex Steroid Metabolic Process White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Keratinocyte Apoptotic Process RZZ Complex Urea Metabolic Process HMG Box Domain Binding Response To Phenylpropanoid Negative Regulation Of Cell Cycle Urea Cycle STAT Family Protein Binding Fat Cell Proliferation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Protein Localization To Chromatin Regulation Of Keratinocyte Apoptotic Process Vitamin D Metabolic Process SUMO Ligase Activity Negative Regulation Of Protein Localization To Chromatin Transferase Complex Positive Regulation Of Protein Sumoylation Protein Localization To Kinetochore Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Osteoblast Development
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