TYW2 and PRDM6

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TYW2	PRDM6
Name		tRNA wybutosine-synthesizing protein 2	PR/SET domain 6
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus
	Molecular Function	Protein Binding TRNA Methyltransferase Activity Transferase Activity TRNA 4-demethylwyosine Alpha-amino-alpha-carboxypropyltransferase Activity	Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Identical Protein Binding Metal Ion Binding Histone H4K20 Monomethyltransferase Activity
	Biological Process	TRNA Modification TRNA Processing TRNA Methylation Wybutosine Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Gene Expression Neurogenesis Methylation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Cell Differentiation
Pathways		Synthesis of wybutosine at G37 of tRNA(Phe)	None
GWAS		No GWAS studies recorded	Body mass index ( 28892062 ) Coronary artery disease ( 29212778 ) Diastolic blood pressure ( 27618447 27841878 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Heart rate increase in response to exercise ( 29497042 ) Heart rate response to recovery post exercise (40 sec) ( 29497042 ) Heart rate response to recovery post exercise (50 sec) ( 29497042 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) Male-pattern baldness ( 28196072 ) Mammographic density (dense area) ( 25342443 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Percent mammographic density ( 25342443 ) Pulse pressure ( 27841878 27618447 ) QRS duration ( 25035420 ) Systolic blood pressure ( 27841878 27618447 26390057 30578418 )
Interacting Genes		3 interacting genes: LNX1 NUDT1 PRDM6	71 interacting genes: ABI2 AGXT AHCYL1 AIRIM ANKS1A AQP1 ARID5A ATOSB ATPAF2 ATXN7L2 BAG3 BANF2 BANP CBFA2T2 CBX8 CCDC120 CCDC57 CCHCR1 CCNL1 CEP57L1 COX5B CSTF2 ELOA ENKD1 EXOSC5 FAM90A1 FHL2 FOXD4L1 FRS3 FTO GADD45GIP1 GEM GPANK1 GRXCR1 HOXC8 IL16 IQUB KANK2 KAT5 KCTD9 KIFC3 LMO1 LMO2 LONRF1 MYOZ3 NCK2 NEK6 NFKBID PATZ1 PIH1D2 PRKAA2 PTK6 QARS1 RAD51D ROPN1 RUNX1T1 SAMD4A SLC19A4P STK16 TCAF1 TEKT4 TLE5 TRIM14 TSGA10 TSGA10IP TSSK3 TTC23 TYW2 UBASH3A USP54 ZFYVE26
Entrez ID		55039	93166
HPRD ID		07947	19698
Ensembl ID		ENSG00000183665	ENSG00000061455
Uniprot IDs		Q53H54	Q9NQX0
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		2-hydroxy-dATP Hydrolase Activity 2-hydroxy-ATP Hydrolase Activity O6-methyl-dGTP Hydrolase Activity DATP Diphosphatase Activity N6-methyl-(d)ATP Hydrolase Activity 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity ATP Diphosphatase Activity Histone H4K20 Monomethyltransferase Activity Purine Nucleoside Catabolic Process DNA Protection 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Nucleobase-containing Small Molecule Catabolic Process Synapse Maturation SnoRNA Binding Negative Regulation Of Smooth Muscle Cell Differentiation Purine Nucleoside Metabolic Process Histone Methyltransferase Activity Nucleoside Metabolic Process Hippocampal Mossy Fiber To CA3 Synapse Regulation Of Smooth Muscle Cell Differentiation Metal Ion Binding	Protein Binding