TRMT61B and CLIP4

Data Source: HiPPIP (Novel)

		TRMT61B	CLIP4
Name		tRNA methyltransferase 61B	CAP-Gly domain containing linker protein family member 4
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix TRNA (m1A) Methyltransferase Complex	Nucleus Cell Cortex Microtubule Plus-end
	Molecular Function	Protein Binding Methyltransferase Activity TRNA (adenine) Methyltransferase Activity RRNA (adenine) Methyltransferase Activity Transferase Activity MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity	Protein Binding Microtubule Plus-end Binding
	Biological Process	MRNA Processing TRNA Processing TRNA Methylation RRNA Methylation Methylation Mitochondrial TRNA Processing	Cytoplasmic Microtubule Organization
Pathways		tRNA modification in the mitochondrion Mitochondrial mRNA modification	None
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Intraocular pressure ( 29617998 )	Metabolite levels ( 23823483 )
Novel Interactors		1 novel interactors: CLIP4	4 novel interactors: PCARE SPDYA TOGARAM2 TRMT61B
Interacting Genes		3 interacting genes: FAM9B IRF7 PPP2CB	37 interacting genes: APP CDK5RAP2 CLIP1 CMYA5 DCAF6 DES DST DYNC2LI1 GLP1R HSF2BP JAKMIP2 KIF1B KIFC3 LZTS2 MAGEA12 MAP7 MAP7D1 MEOX2 MYBPC1 MYH3 PDE4DIP PEG10 RPS13 RPS27L RUNX1 SIX2 SON TACC3 TAF1 TNNT1 TNNT3 TPM1 TRIM32 TRIP13 TTN TULP3 ZNF114
Entrez ID		55006	79745
HPRD ID		07935	08634
Ensembl ID		ENSG00000171103	ENSG00000115295
Uniprot IDs		F8WDR2 Q9BVS5	A0A8I5KXU9 A0A8I5QKP4 A0A8I5QKV0 A8K6D0 B7Z936 G3XAK3 Q8N3C7
PDB IDs		2B25	2Z0W
GO Terms Enriched among Interactors		Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Establishment Of Viral Latency Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Macrophage Apoptotic Process	Cytoskeleton Organization Sarcomere Organization Organelle Organization Microtubule-based Process Microtubule Cytoskeleton Organization Actomyosin Structure Organization Microtubule Skeletal Muscle Contraction Striated Muscle Contraction Microtubule Binding Muscle Filament Sliding Muscle Contraction Actin-myosin Filament Sliding Centrosome Actin Cytoskeleton Organization Cytoskeleton Microtubule Plus-end Microtubule Cytoskeleton Muscle System Process M Band Actin Filament-based Process Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Microtubule Polymerization Actin-mediated Cell Contraction Female Meiosis I Structural Constituent Of Muscle Troponin Complex Myofibril Male Meiotic Nuclear Division Regulation Of Supramolecular Fiber Organization Actin Filament-based Movement Contractile Muscle Fiber Tropomyosin Binding Regulation Of Microtubule Polymerization Cytoskeletal Protein Binding Regulation Of Microtubule Cytoskeleton Organization Transport Along Microtubule Meiotic Nuclear Division Female Meiotic Nuclear Division Axo-dendritic Transport Positive Regulation Of Cytoskeleton Organization Supramolecular Fiber Organization Retrograde Axonal Transport Microtubule Plus-end Binding Positive Regulation Of Protein Polymerization Cytoskeleton-dependent Intracellular Transport Myosin Filament Nuclear Division Regulation Of Cytoskeleton Organization Amyloid-beta Complex