PLPPR1 and SERP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLPPR1	SERP1
Description		phospholipid phosphatase related 1	stress associated endoplasmic reticulum protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane Cell Projection Neuron Projection	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Ribosome Cytoplasmic Microtubule Membrane
	Molecular Function	Protein Binding Phosphatidate Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity	Protein Binding
	Biological Process	Phospholipid Metabolic Process Signal Transduction Nervous System Development Phospholipid Dephosphorylation	Skeletal System Development Glucose Metabolic Process Protein Glycosylation Response To Unfolded Protein Plasma Membrane Organization Post-embryonic Development Protein Transport Insulin Secretion Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Insulin Secretion Protein Modification Process Positive Regulation Of Translation Positive Regulation Of Organ Growth Muscle Organ Morphogenesis Positive Regulation Of Growth Hormone Secretion
Pathways		Lysosphingolipid and LPA receptors	XBP1(S) activates chaperone genes Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Hip circumference adjusted for BMI ( 28552196) Triglyceride levels in HIV infection ( 33109212)	Academic attainment (English) ( 33594131)
Interacting Genes		5 interacting genes: LEPROT PLN SERP1 SLC30A2 TMPPE	56 interacting genes: ALG3 APH1A APP AQP6 AQP8 BIK BSCL2 CANX CD74 CD79A CRB3 CYBRD1 EBP FAM174A FAM209A FAM210B FKBP7 FRMD3 GJB3 GJB5 GKN1 GPR37L1 GPX8 HSD17B13 IL3RA JAGN1 KCNF1 KIR3DL3 LHFPL5 LMNA MTIF3 PLPPR1 REEP4 SAR1A SCNN1A SCNN1G SEC11C SEC61A1 SEC61B SLC10A1 SLC10A6 SLC18A1 SLC22A1 SLC22A2 SLC35H1 SLC71A2 SSMEM1 STX1A STX2 STX4 TIMMDC1 TLCD4 TMEM14B TMEM52B TMEM79 TNFRSF9
Entrez ID		54886	27230
HPRD ID		17906	18037
Ensembl ID		ENSG00000148123	ENSG00000120742
Uniprot IDs		Q8TBJ4	Q9Y6X1
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Zinc Ion Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Response To Unfolded Protein Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Cellular Homeostasis Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Zinc Export Across Plasma Membrane Circadian Sleep/wake Cycle Process Vacuolar Transport Zinc Ion Import Into Lysosome ATPase Inhibitor Activity Zinc:proton Antiporter Activity Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Transporter Inhibitor Activity Regulation Of Relaxation Of Cardiac Muscle G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Sleep Vacuolar Transmembrane Transport Response To Endoplasmic Reticulum Stress Muscle Organ Morphogenesis Secretory Vesicle Positive Regulation Of Growth Hormone Secretion Negative Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of ATP-dependent Activity Locomotor Rhythm Endoplasmic Reticulum Membrane Negative Regulation Of Heart Rate Endosome Membrane Zinc Ion Import Into Organelle Negative Regulation Of Protein Localization To Cell Surface Regulation Of Growth Hormone Receptor Signaling Pathway Relaxation Of Cardiac Muscle Regulation Of Growth Hormone Secretion Negative Regulation Of Calcium Ion Import Positive Regulation Of Establishment Of Protein Localization Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Response To Metal Ion Regulation Of Relaxation Of Muscle Zymogen Granule Membrane Monoatomic Cation Transmembrane Transporter Activity Relaxation Of Muscle Circadian Behavior	Membrane Transmembrane Transport Norepinephrine Uptake Endoplasmic Reticulum Serotonin Uptake Norepinephrine Transport Monoamine Transmembrane Transporter Activity Amine Transport Catecholamine Uptake Dopamine Uptake Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Protein Binding Neurotransmitter Transport Apical Plasma Membrane Mitochondrial Membrane Endoplasmic Reticulum Membrane Putrescine Transmembrane Transporter Activity Monoatomic Ion Transport Neurotransmitter Reuptake Dopamine Transport Sensory Perception Of Salty Taste Xenobiotic Transmembrane Transporter Activity Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Bile Acid:sodium Symporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Monoamine Transport Neurotransmitter Uptake Lumenal Side Of Endoplasmic Reticulum Membrane Basolateral Plasma Membrane External Side Of Plasma Membrane Cornified Envelope Assembly Monoatomic Cation Transport Xenobiotic Transport Across Blood-brain Barrier Sec61 Translocon Complex Import Into Cell Organic Cation Transport Organic Hydroxy Compound Transport Cellular Response To Aldosterone Sodium Channel Complex Toxin Transmembrane Transporter Activity
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