ERCC6L and LMO4

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		ERCC6L	LMO4
Name		ERCC excision repair 6 like, spindle assembly checkpoint helicase	LIM domain only 4
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytosol Membrane	Nucleus Transcription Regulator Complex Cell Leading Edge RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding DNA Binding Helicase Activity Protein Binding ATP Binding DNA Translocase Activity Hydrolase Activity ATP Hydrolysis Activity	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	DNA Repair Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Tissue Development Ventral Spinal Cord Interneuron Differentiation Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Spinal Cord Association Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Kinase Activity Regulation Of Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Regulation Of Developmental Process Regulation Of Cell Activation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	None
GWAS		Autism spectrum disorder ( 34069769 )	Academic attainment (English) ( 33594131 ) Age at first sexual intercourse ( 34211149 ) Alanine aminotransferase levels ( 33547301 ) Angiotensin-converting enzyme inhibitor intolerance ( 28030426 ) Aspartate aminotransferase levels ( 33547301 ) Breast cancer ( 27354352 ) Eosinophil count ( 29403010 ) Gait rhythm ( 26219847 ) Glaucoma (primary open-angle) ( 29891935 ) Photic sneeze reflex ( 27182965 ) Prostate-specific antigen levels ( 28139693 ) Response to TNF antagonist treatment ( 18615156 ) Resting heart rate ( 27798624 ) White blood cell count (basophil) ( 29403010 ) White blood cell types ( 21738478 )
Interacting Genes		6 interacting genes: CDK1 CFTR HTT LMO4 PLK1 ZDHHC17	131 interacting genes: AARD ABI2 ADAMTSL4 AMOT AMOTL2 ARNT2 BANP BBS2 BCAS2 BIRC7 BRCA1 CALCOCO2 CCDC102B CCDC120 CEP170P1 COG6 CRNN CRYBB2 CSNK2B CTBP2 CYSRT1 DDB1 DEAF1 DES ECM1 ERCC6L EXOSC8 FAM228A FHL3 GABPB1 GADD45A GOLGA2 GOLGA6L9 GRHL2 GSK3B HELT HGS HSF2BP ID3 IKZF1 IKZF3 ITSN1 KANK2 KATNBL1 KIAA1958 KIF3B KPNA1 KRT15 KRT31 KRT33B KRT34 KRT38 KRT39 KRT40 KRT74 KRT75 KRT76 KRTAP11-1 KRTAP3-1 KYNU L3MBTL3 LASP1 LDB1 LDB2 LMO2 LZTS1 MCCD1 MERTK METTL27 MID2 MTA1 MTUS2 MYOD1 MYOZ3 N4BP3 NFKBID NFYC NHLH1 NME4 NONO NRF1 PDE4DIP PELO PER2 PITPNB PLK1 PPARG QRICH1 RBAK RBBP8 RBPMS RCN1 REDIC1 RLIM RNF8 ROPN1 RPS6KA6 RSPH6A SAXO4 SEC24D SLC15A2 SMAD4 SMAD9 STAT5B SUOX TCF21 TCF4 TEX14 TFIP11 TINAGL1 TLE5 TNFSF11 TP53BP2 TRAF5 TRIM27 TRIM54 TSEN15 TTLL7 UBQLN2 VMAC VPS52 WASHC1 ZBTB43 ZMYND12 ZNF135 ZNF202 ZNF213 ZNF397 ZNF410 ZNF467 ZNF675
Entrez ID		54821	8543
HPRD ID		10974	09122
Ensembl ID		ENSG00000186871	ENSG00000143013
Uniprot IDs		B5MDQ0 Q2NKX8	P61968
PDB IDs		5JNO	9F5B
GO Terms Enriched among Interactors		Mitotic Nuclear Membrane Disassembly Golgi Organization Microtubule Cytoskeleton Organization Involved In Mitosis Membrane Disassembly Nuclear Membrane Disassembly Golgi-associated Vesicle Membrane Protein Localization To Site Of Double-strand Break Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Condensation Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Establishment Of Mitotic Spindle Orientation Spindle Microtubule Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nuclear Membrane Organization Centrosome Cycle Mitotic G2/M Transition Checkpoint G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Establishment Of Spindle Localization Protein Destabilization Spindle Localization Regulation Of Cellular Component Organization Negative Regulation Of Cell Cycle G2/M Phase Transition Pronuclear Fusion Mitotic DNA Integrity Checkpoint Signaling Microtubule Organizing Center Organization Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Positive Regulation Of Protein Localization Mitotic DNA Damage Checkpoint Signaling Regulation Of Transmembrane Transporter Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Monoatomic Ion Transmembrane Transporter Activity Perforant Pathway To Dendrate Granule Cell Synapse Organelle Localization Positive Regulation Of Protein Localization To Nucleus DNA Damage Checkpoint Signaling Protein Localization To Chromosome Mitotic DNA-templated DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Regulation Of Programmed Cell Death Regulation Of Cell Cycle G2/M Phase Transition Cyclin A2-CDK1 Complex	Protein Binding Intermediate Filament Organization Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Structural Molecule Activity Supramolecular Fiber Organization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Organelle Organization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Regulator Complex Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Cytoskeleton Regulation Of Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Epithelial Cell Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Centrosome Cycle Positive Regulation Of RNA Metabolic Process Microtubule-based Process Microtubule Cytoskeleton Organization DNA-binding Transcription Factor Activity BHLH Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity RNA Polymerase II Transcription Regulator Complex