ERCC6L

Name	ERCC excision repair 6 like, spindle assembly checkpoint helicase
Structure
Interactors	6 interactors: CDK1 CFTR HTT LMO4 PLK1 ZDHHC17
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytosol Membrane
	Molecular Function	Nucleotide Binding DNA Binding Helicase Activity Protein Binding ATP Binding DNA Translocase Activity Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	DNA Repair Cell Division
Pathways	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS	Autism spectrum disorder ( 34069769 )
Entrez ID	54821
HPRD ID	10974
Ensembl ID	ENSG00000186871
Uniprot IDs	B5MDQ0 Q2NKX8
PDB IDs	5JNO
GO Terms Enriched among Interactors ?	Mitotic Nuclear Membrane Disassembly Golgi Organization Microtubule Cytoskeleton Organization Involved In Mitosis Membrane Disassembly Nuclear Membrane Disassembly Golgi-associated Vesicle Membrane Protein Localization To Site Of Double-strand Break Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Condensation Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Establishment Of Mitotic Spindle Orientation Spindle Microtubule Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nuclear Membrane Organization Centrosome Cycle Mitotic G2/M Transition Checkpoint G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Establishment Of Spindle Localization Protein Destabilization Spindle Localization Regulation Of Cellular Component Organization Negative Regulation Of Cell Cycle G2/M Phase Transition Pronuclear Fusion Mitotic DNA Integrity Checkpoint Signaling Microtubule Organizing Center Organization Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Positive Regulation Of Protein Localization Mitotic DNA Damage Checkpoint Signaling Regulation Of Transmembrane Transporter Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Monoatomic Ion Transmembrane Transporter Activity Perforant Pathway To Dendrate Granule Cell Synapse Organelle Localization Positive Regulation Of Protein Localization To Nucleus DNA Damage Checkpoint Signaling Protein Localization To Chromosome Mitotic DNA-templated DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Regulation Of Programmed Cell Death Regulation Of Cell Cycle G2/M Phase Transition Cyclin A2-CDK1 Complex